| 19. Jornada | 22.01.2022 | CyD Leonesa | - | Real Unión | 1:1 | ||||
| 20. Jornada | 25.01.2022 | Bilbao Athletic | - | CyD Leonesa | 1:2 | ||||
| 24. Jornada | 19.02.2022 | Extremadura UD | - | CyD Leonesa | 1:3 | ||||
| 26. Jornada | 04.03.2022 | Rayo Majadahonda | - | CyD Leonesa | 1:0 | ||||
| 22. Jornada | 09.03.2022 | Real Racing | - | CyD Leonesa | 4:0 | ||||
| 30. Jornada | 03.04.2022 | Real Unión | - | CyD Leonesa | 1:1 | ||||
| 31. Jornada | 09.04.2022 | CyD Leonesa | - | Racing de Ferrol | 0:2 |  |
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| 33. Jornada | 24.04.2022 | Valladolid B | - | CyD Leonesa | 3:3 | ||||
| 34. Jornada | 01.05.2022 | CyD Leonesa | - | Zamora CF | 0:0 | ||||
| 35. Jornada | 08.05.2022 | Celta B | - | CyD Leonesa | 5:3 | ||||
| 37. Jornada | 21.05.2022 | CF Talavera | - | CyD Leonesa | 0:5 |
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