| 6. Jornada | 31.07.2022 | Santos Laguna [Sub 20] | - | Atlas Guadalajara [Sub 20] | 1:1 |  |
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| 1. Jornada | 03.08.2022 | Santos Laguna [Sub 20] | - | CF Monterrey [Sub 20] | 2:1 | ||||
| 7. Jornada | 06.08.2022 | Santos Laguna [Sub 20] | - | Cruz Azul [Sub 20] | 2:1 | |
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| 8. Jornada | 14.08.2022 | UANL Tigres [Sub 20] | - | Santos Laguna [Sub 20] | 2:2 | |
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| 9. Jornada | 18.08.2022 | Santos Laguna [Sub 20] | - | Club León [Sub 20] | 2:3 | ||||
| 10. Jornada | 21.08.2022 | Pumas UNAM [Sub 20] | - | Santos Laguna [Sub 20] | 0:1 |  |
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| 16. Jornada | 26.08.2022 | Club Tijuana [Sub 20] | - | Santos Laguna [Sub 20] | 1:1 | ||||
| 11. Jornada | 28.08.2022 | Santos Laguna [Sub 20] | - | Atlético San Luis [Sub 20] | 7:2 | |
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| 12. Jornada | 03.09.2022 | CF Pachuca [Sub 20] | - | Santos Laguna [Sub 20] | 5:1 | ||||
| 13. Jornada | 06.09.2022 | Santos Laguna [Sub 20] | - | Club Necaxa [Sub 20] | 3:2 | |
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| 14. Jornada | 10.09.2022 | Gallos Blancos [Sub 20] | - | Santos Laguna [Sub 20] | 2:2 | |
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| 15. Jornada | 18.09.2022 | Santos Laguna [Sub 20] | - | FC Juárez [Sub 20] | 3:0 | ||||
| 17. Jornada | 02.10.2022 | Santos Laguna [Sub 20] | - | Mazatlán FC [Sub 20] | 2:3 |
México