| 1. Jornada | 04.06.2022 | River Plate II | - | Defensa y Justicia II | 2:0 |  |
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| 2. Jornada | 09.06.2022 | Atlético Tucumán II | - | River Plate II | 1:0 | ||||
| 3. Jornada | 14.06.2022 | River Plate II | - | Colón de Santa Fe II | 0:2 | ||||
| 4. Jornada | 18.06.2022 | River Plate II | - | Unión de Santa Fe II | 2:0 | ||||
| 5. Jornada | 24.06.2022 | Lanús II | - | River Plate II | 1:5 | ||||
| 6. Jornada | 02.07.2022 | River Plate II | - | Huracán II | 1:0 | ||||
| 7. Jornada | 09.07.2022 | Godoy Cruz II | - | River Plate II | 0:1 | ||||
| 9. Jornada | 20.07.2022 | Gimnasia de La Plata II | - | River Plate II | 1:3 | ||||
| 10. Jornada | 25.07.2022 | River Plate II | - | Aldosivi II | 2:0 | ||||
| 11. Jornada | 30.07.2022 | Sarmiento de Junín II | - | River Plate II | 0:1 | ||||
| 12. Jornada | 06.08.2022 | River Plate II | - | Independiente II | 2:1 | ||||
| 13. Jornada | 11.08.2022 | Newell's Old Boys II | - | River Plate II | 2:0 | ||||
| 17. Jornada | 03.09.2022 | Barracas Central II | - | River Plate II | 2:1 | ||||
| 26. Jornada | 16.10.2022 | Rosario Central II | - | River Plate II | 3:3 | ||||
| 27. Jornada | 20.10.2022 | River Plate II | - | Racing Club II | 1:2 |
Argentina