| 1. Jornada | 25.07.2021 | Pumas UNAM | - | Atlas Guadalajara | 0:0 | ||||
| 2. Jornada | 01.08.2021 | CF Monterrey | - | Pumas UNAM | 2:0 | ||||
| 3. Jornada | 08.08.2021 | Pumas UNAM | - | Atlético San Luis | 1:3 |  |
|||
| 5. Jornada | 18.08.2021 | Club Necaxa | - | Pumas UNAM | 3:0 | ||||
| 6. Jornada | 22.08.2021 | Pumas UNAM | - | Puebla FC | 2:0 | ||||
| 7. Jornada | 29.08.2021 | Deportivo Toluca | - | Pumas UNAM | 2:1 | |
|||
| 8. Jornada | 13.09.2021 | Pumas UNAM | - | Deportivo Guadalajara | 0:0 | ||||
| 9. Jornada | 19.09.2021 | Mazatlán FC | - | Pumas UNAM | 2:2 | ||||
| 10. Jornada | 26.09.2021 | UANL Tigres | - | Pumas UNAM | 0:0 | ||||
| 12. Jornada | 04.10.2021 | CF América | - | Pumas UNAM | 2:0 | ||||
| 14. Jornada | 21.10.2021 | Club León | - | Pumas UNAM | 1:2 | |
|||
| 15. Jornada | 24.10.2021 | Pumas UNAM | - | Club Tijuana | 3:1 | |
|||
| 16. Jornada | 31.10.2021 | CF Pachuca | - | Pumas UNAM | 1:1 | ||||
| 11. Jornada | 05.11.2021 | Pumas UNAM | - | Santos Laguna | 0:3 | ||||
| 17. Jornada | 08.11.2021 | Pumas UNAM | - | Cruz Azul | 4:3 |
México