| 1. Jornada | 27.07.2021 | Cruz Azul | - | Mazatlán FC | 0:2 |  |
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| 2. Jornada | 31.07.2021 | Mazatlán FC | - | CF Pachuca | 2:1 |  |
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| 3. Jornada | 07.08.2021 | Mazatlán FC | - | CF Monterrey | 1:1 | ||||
| 4. Jornada | 15.08.2021 | Club León | - | Mazatlán FC | 3:0 | |
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| 5. Jornada | 18.08.2021 | Deportivo Toluca | - | Mazatlán FC | 2:2 | |
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| 6. Jornada | 21.08.2021 | Mazatlán FC | - | UANL Tigres | 0:3 | ||||
| 7. Jornada | 28.08.2021 | Mazatlán FC | - | Atlético San Luis | 2:2 | ||||
| 8. Jornada | 12.09.2021 | CF América | - | Mazatlán FC | 2:0 | |
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| 9. Jornada | 19.09.2021 | Mazatlán FC | - | Pumas UNAM | 2:2 | ||||
| 10. Jornada | 25.09.2021 | Club Tijuana | - | Mazatlán FC | 0:0 | ||||
| 11. Jornada | 29.09.2021 | Mazatlán FC | - | FC Juárez | 3:1 | ||||
| 12. Jornada | 03.10.2021 | Santos Laguna | - | Mazatlán FC | 1:0 | |
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| 14. Jornada | 20.10.2021 | Puebla FC | - | Mazatlán FC | 2:0 | ||||
| 15. Jornada | 23.10.2021 | Mazatlán FC | - | Gallos Blancos | 2:1 | ||||
| 16. Jornada | 30.10.2021 | Club Necaxa | - | Mazatlán FC | 2:1 | ||||
| 17. Jornada | 06.11.2021 | Mazatlán FC | - | Deportivo Guadalajara | 0:1 | |
Chile