| 1. Jornada | 10.02.2022 | Sarmiento de Junín | - | Atlético Tucumán | 1:0 |  |
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| 4. Jornada | 02.03.2022 | Atlético Tucumán | - | Patronato de Paraná | 1:0 | ||||
| 5. Jornada | 06.03.2022 | Newell's Old Boys | - | Atlético Tucumán | 4:0 | |
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| 6. Jornada | 14.03.2022 | Atlético Tucumán | - | Racing Club | 0:4 | ||||
| 7. Jornada | 22.03.2022 | Atlético Tucumán | - | Central Córdoba SdE | 0:1 | ||||
| 8. Jornada | 03.04.2022 | San Lorenzo | - | Atlético Tucumán | 1:1 | ||||
| 9. Jornada | 09.04.2022 | Atlético Tucumán | - | Gimnasia de La Plata | 1:2 | ||||
| 10. Jornada | 17.04.2022 | Defensa y Justicia | - | Atlético Tucumán | 1:1 | ||||
| 11. Jornada | 21.04.2022 | Atlético Tucumán | - | Argentinos Juniors | 2:4 |
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