| 1. Jornada | 24.07.2021 | CF Pachuca | - | Club León | 4:0 | ||||
| 2. Jornada | 31.07.2021 | Mazatlán FC | - | CF Pachuca | 2:1 | ||||
| 3. Jornada | 10.08.2021 | CF Pachuca | - | Atlas Guadalajara | 0:1 |  |
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| 4. Jornada | 15.08.2021 | CF Monterrey | - | CF Pachuca | 3:1 |  |
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| 6. Jornada | 23.08.2021 | Gallos Blancos | - | CF Pachuca | 0:2 | ||||
| 7. Jornada | 30.08.2021 | Cruz Azul | - | CF Pachuca | 1:1 | |
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| 8. Jornada | 14.09.2021 | CF Pachuca | - | Deportivo Toluca | 1:2 | ||||
| 9. Jornada | 19.09.2021 | Deportivo Guadalajara | - | CF Pachuca | 1:0 | ||||
| 11. Jornada | 29.09.2021 | CF Pachuca | - | CF América | 1:1 | ||||
| 13. Jornada | 17.10.2021 | CF Pachuca | - | Santos Laguna | 1:1 | |
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| 14. Jornada | 21.10.2021 | UANL Tigres | - | CF Pachuca | 3:0 | |
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| 15. Jornada | 25.10.2021 | CF Pachuca | - | FC Juárez | 1:1 | ||||
| 16. Jornada | 31.10.2021 | CF Pachuca | - | Pumas UNAM | 1:1 | |
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| 5. Jornada | 04.11.2021 | CF Pachuca | - | Atlético San Luis | 0:0 | ||||
| 17. Jornada | 07.11.2021 | Club Tijuana | - | CF Pachuca | 3:2 | |
Colombia