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| I | ENPPI | - | St. George SC | 0:0 | ||
| V | St. George SC | - | ENPPI | 1:0 | ||
| I: 17.02.2006 16:00 | V: 05.03.2006 | Campeones: St. George SC | ||||
| I | Tusker FC | - | Red Sea FC | 3:1 | ||
| V | Red Sea FC | - | Tusker FC | 0:1 | ||
| I: 18.02.2006 | V: 07.03.2006 | Campeones: Tusker FC | ||||
| I | Civics FC | - | GD Sagrada Esperança | 4:0 | ||
| V | GD Sagrada Esperança | - | Civics FC | 2:1 | ||
| I: 18.02.2006 | V: 05.03.2006 | Campeones: Civics FC | ||||
| I | Police XI FC | - | Enugu Rangers | 2:2 | ||
| V | Enugu Rangers | - | Police XI FC | 1:0 | ||
| I: 18.02.2006 | V: 04.03.2006 | Campeones: Enugu Rangers | ||||
| I | FC St. Eloi Lupopo | - | AS Police | 2:0 | ||
| V | AS Police | - | FC St. Eloi Lupopo | 1:2 | ||
| I: 18.02.2006 | V: 04.03.2006 | Campeones: FC St. Eloi Lupopo | ||||
| I | APR FC | - | AS Aviação | 3:2 | ||
| V | AS Aviação | - | APR FC | 0:1 | ||
| I: 18.02.2006 | V: 05.03.2006 | Campeones: APR FC | ||||
| I | Young Africans | - | Zanaco FC | 2:1 | ||
| V | Zanaco FC | - | Young Africans | 2:0 | ||
| I: 18.02.2006 | V: 04.03.2006 | Campeones: Zanaco FC | ||||
| I | Police FC | - | Al Hilal Omdurman | 0:0 | ||
| V | Al Hilal Omdurman | - | Police FC | 3:0 | ||
| I: 18.02.2006 14:30 | V: 05.03.2006 | Campeones: Al Hilal Omdurman | ||||
| I | AS FNIS | - | CS Sfaxien | 1:3 | ||
| V | CS Sfaxien | - | AS FNIS | 4:0 | ||
| I: 18.02.2006 16:00 | V: 04.03.2006 | Campeones: CS Sfaxien | ||||
| I | Renacimiento FC | - | Africa Sports | 0:0 | ||
| V | Africa Sports | - | Renacimiento FC | 2:2 | ||
| I: 19.02.2006 | V: 04.03.2006 | Campeones: Renacimiento FC | ||||
| I | Stade Malien | - | Satellite FC | 3:0 | ||
| V | Satellite FC | - | Stade Malien | 2:2 | ||
| I: 19.02.2006 | V: 05.03.2006 | Campeones: Stade Malien | ||||
| I | RC Kadiogo | - | USM Alger | 1:1 | ||
| V | USM Alger | - | RC Kadiogo | 1:0 | ||
| I: 19.02.2006 | V: 03.03.2006 | Campeones: USM Alger | ||||
| I | AS Douanes | - | Port Autonome | 0:0 | ||
| V | Port Autonome | - | AS Douanes | 3:2 | ||
| I: 19.02.2006 | V: 04.03.2006 | Campeones: Port Autonome | ||||
| I | East End Lions | - | ASEC Mimosas | 0:4 | ||
| V | ASEC Mimosas | - | East End Lions | 3:0 | ||
| I: 19.02.2006 | V: 05.03.2006 | Campeones: ASEC Mimosas | ||||
| I | Mbabane Swallows | - | Orlando Pirates | 0:5 | ||
| V | Orlando Pirates | - | Mbabane Swallows | 2:2 | ||
| I: 19.02.2006 | V: 04.03.2006 | Campeones: Orlando Pirates | ||||
| I | AS Port Louis 2000 | - | Coin Nord Mitsamiouli | 1:0 pró. | ||
| V | Coin Nord Mitsamiouli | - | AS Port Louis 2000 | no jug. | ||
| I: 19.02.2006 | V: 05.03.2006 | Campeones: AS Port Louis 2000 | ||||
| I | Mangasport Moanda | - | Enyimba Aba | 1:0 | ||
| V | Enyimba Aba | - | Mangasport Moanda | 2:0 | ||
| I: 19.02.2006 | V: 05.03.2006 | Campeones: Enyimba Aba | ||||
| I | LPRC Oilers | - | ASC Diaraf | 0:0 | ||
| V | ASC Diaraf | - | LPRC Oilers | 3:2 | ||
| I: 19.02.2006 | V: 05.03.2006 | Campeones: ASC Diaraf | ||||
| I | Renaissance FC | - | Coton Sport Garoua | 1:1 | ||
| V | Coton Sport Garoua | - | Renaissance FC | 1:0 | ||
| I: 19.02.2006 | V: 04.03.2006 | Campeones: Coton Sport Garoua | ||||
| I | Anges de Fatima | - | DC Motema Pembe | 0:0 | ||
| V | DC Motema Pembe | - | Anges de Fatima | 2:0 | ||
| I: 19.02.2006 | V: 05.03.2006 | Campeones: DC Motema Pembe | ||||
| I | Aigle Royal de la Menoua | - | Asante Kotoko | 1:1 | ||
| V | Asante Kotoko | - | Aigle Royal de la Menoua | 3:0 | ||
| I: 19.02.2006 | V: 05.03.2006 | Campeones: Asante Kotoko | ||||
| I | La Passe FC | - | Clube Ferroviário Maputo | 0:0 | ||
| V | Clube Ferroviário Maputo | - | La Passe FC | 2:0 | ||
| I: 19.02.2006 | V: 05.03.2006 | Campeones: Clube Ferroviário Maputo | ||||
| I | Likhopo | - | Mamelodi Sundowns | 0:1 | ||
| V | Mamelodi Sundowns | - | Likhopo | 3:0 | ||
| I: 19.02.2006 | V: 05.03.2006 | Campeones: Mamelodi Sundowns | ||||
| I | AS Excelsior | - | Uscafoot Analamanga | 3:1 | ||
| V | Uscafoot Analamanga | - | AS Excelsior | 2:0 | ||
| I: 19.02.2006 | V: 05.03.2006 | Campeones: Uscafoot Analamanga | ||||
| I | Al Ittihad Tripolis | - | JS Kabylie | 1:1 | ||
| V | JS Kabylie | - | Al Ittihad Tripolis | 4:0 | ||
| I: 19.02.2006 | V: 05.03.2006 | Campeones: JS Kabylie | ||||
| I | Inter Star | - | CAPS United | 3:3 | ||
| V | CAPS United | - | Inter Star | 1:1 | ||
| I: 19.02.2006 | V: 05.03.2006 | Campeones: CAPS United | ||||
