| 2. Jornada | 01.08.2021 | Club León | - | Club Tijuana | 2:1 | ||||
| 3. Jornada | 06.08.2021 | Gallos Blancos | - | Club León | 0:1 | ||||
| 4. Jornada | 15.08.2021 | Club León | - | Mazatlán FC | 3:0 | ||||
| 5. Jornada | 19.08.2021 | Deportivo Guadalajara | - | Club León | 0:3 | ||||
| 6. Jornada | 22.08.2021 | Club León | - | Santos Laguna | 1:1 | ||||
| 7. Jornada | 29.08.2021 | Club León | - | CF América | 1:1 | ||||
| 8. Jornada | 12.09.2021 | UANL Tigres | - | Club León | 2:2 | ||||
| 9. Jornada | 19.09.2021 | Club León | - | FC Juárez | 0:1 | ||||
| 10. Jornada | 26.09.2021 | Atlas Guadalajara | - | Club León | 2:0 | ||||
| 12. Jornada | 03.10.2021 | Club León | - | Atlético San Luis | 0:0 | ||||
| 13. Jornada | 17.10.2021 | CF Monterrey | - | Club León | 0:1 | ||||
| 15. Jornada | 24.10.2021 | Puebla FC | - | Club León | 0:1 | ||||
| 16. Jornada | 31.10.2021 | Deportivo Toluca | - | Club León | 0:0 | ||||
| 11. Jornada | 04.11.2021 | Cruz Azul | - | Club León | 0:1 | ||||
| 17. Jornada | 07.11.2021 | Club León | - | Club Necaxa | 3:0 |
Colombia