| 1. Jornada | 08.08.2021 | FC Metz | - | Lille | 3:3 | ||||
| 2. Jornada | 14.08.2021 | Lille | - | Niza | 0:4 | ||||
| 3. Jornada | 21.08.2021 | Saint-Étienne | - | Lille | 1:1 | ||||
| 4. Jornada | 29.08.2021 | Lille | - | Montpellier | 2:1 | ||||
| 5. Jornada | 10.09.2021 | Lorient | - | Lille | 2:1 | ||||
| 6. Jornada | 18.09.2021 | RC Lens | - | Lille | 1:0 |  |
|||
| 8. Jornada | 25.09.2021 | RC Strasbourg | - | Lille | 1:2 | |
|||
| 9. Jornada | 03.10.2021 | Lille | - | Marsella | 2:0 | |
|||
| 11. Jornada | 23.10.2021 | Lille | - | Stade Brestois 29 | 1:1 | |
|||
| 12. Jornada | 29.10.2021 | París Saint-Germain | - | Lille | 2:1 | |
|||
| 13. Jornada | 06.11.2021 | Lille | - | Angers | 1:1 | ||||
| 15. Jornada | 27.11.2021 | Lille | - | Nantes | 1:1 | ||||
| 16. Jornada | 01.12.2021 | Rennes | - | Lille | 1:2 | |
|||
| 17. Jornada | 04.12.2021 | Lille | - | Troyes | 2:1 | ||||
| 19. Jornada | 22.12.2021 | Girondins de Burdeos | - | Lille | 2:3 | ||||
| 21. Jornada | 16.01.2022 | Marsella | - | Lille | 1:1 | ||||
| 20. Jornada | 19.01.2022 | Lille | - | Lorient | 3:1 |  |
|||
| 22. Jornada | 22.01.2022 | Stade Brestois 29 | - | Lille | 2:0 | |
Mozambique