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| 14.05.2022 | 18:30 | Espanyol | - | Valencia | 1:1 (1:1) | |
| 15.05.2022 | 19:30 | Athletic | - | Osasuna | 2:0 (1:0) | |
| 19:30 | Atlético | - | Sevilla | 1:1 (1:0) | ||
| 19:30 | Betis | - | Granada | 2:0 (1:0) | ||
| 19:30 | Celta | - | Elche | 1:0 (1:0) | ||
| 19:30 | Cádiz CF | - | Real Madrid | 1:1 (1:1) | ||
| 19:30 | Getafe | - | Barcelona | 0:0 (0:0) | ||
| 19:30 | Villarreal | - | Real Sociedad | 1:2 (1:0) | ||
| 19:30 | Mallorca | - | Rayo | 2:1 (1:0) | ||
| 19:30 | Levante | - | Alavés | 3:1 (0:1) |
| » Clasificación | En casa | Fuera de casa | 1.ª vuelta | 2.ª vuelta | 1.ª parte | 2.ª parte |
| # | Equipo | P | V | E | D | Goles | DG | Pun. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Real Madrid | 37 | 26 | 7 | 4 | 80:31 | 49 | 85 |
| 2 |
|
Barcelona | 37 | 21 | 10 | 6 | 68:36 | 32 | 73 |
| 3 |
|
Atlético | 37 | 20 | 8 | 9 | 63:42 | 21 | 68 |
| 4 |
|
Sevilla | 37 | 17 | 16 | 4 | 52:30 | 22 | 67 |
| 5 |
|
Betis | 37 | 19 | 7 | 11 | 62:40 | 22 | 64 |
| 6 |
|
Real Sociedad | 37 | 17 | 11 | 9 | 39:35 | 4 | 62 |
| 7 |
|
Villarreal | 37 | 15 | 11 | 11 | 61:37 | 24 | 56 |
| 8 |
|
Athletic | 37 | 14 | 13 | 10 | 43:35 | 8 | 55 |
| 9 |
|
Osasuna | 37 | 12 | 11 | 14 | 37:49 | -12 | 47 |
| 10 |
|
Celta | 37 | 12 | 10 | 15 | 43:41 | 2 | 46 |
| 11 |
|
Valencia | 37 | 10 | 15 | 12 | 46:53 | -7 | 45 |
| 12 |
|
Rayo | 37 | 11 | 9 | 17 | 37:46 | -9 | 42 |
| 13 |
|
Espanyol | 37 | 10 | 11 | 16 | 40:53 | -13 | 41 |
| 14 |
|
Getafe | 37 | 8 | 15 | 14 | 32:38 | -6 | 39 |
| 15 |
|
Elche | 37 | 10 | 9 | 18 | 37:51 | -14 | 39 |
| 16 |
|
Granada | 37 | 8 | 13 | 16 | 44:61 | -17 | 37 |
| 17 |
|
Mallorca | 37 | 9 | 9 | 19 | 34:63 | -29 | 36 |
| 18 |
|
Cádiz CF | 37 | 7 | 15 | 15 | 34:51 | -17 | 36 |
| 19 |
|
Levante | 37 | 7 | 11 | 19 | 47:74 | -27 | 32 |
| 20 |
|
Alavés | 37 | 8 | 7 | 22 | 31:64 | -33 | 31 |
| Champions League | |
| Europa League | |
| ECL Ronda previa | |
| Descenso |
