| 10. Jornada | 20.11.2021 | Tottenham Hotspur [Sub 18] | - | Southampton FC [Sub 18] | 0:3 | ||||
| 17. Jornada | 19.02.2022 | Southampton FC [Sub 18] | - | West Bromwich Albion [Sub 18] | 2:1 | ||||
| 19. Jornada | 05.03.2022 | Southampton FC [Sub 18] | - | Norwich City [Sub 18] | 5:0 | ||||
| 20. Jornada | 12.03.2022 | Birmingham City [Sub 18] | - | Southampton FC [Sub 18] | 1:4 | ||||
| 21. Jornada | 19.03.2022 | Southampton FC [Sub 18] | - | West Ham United [Sub 18] | 0:0 | ||||
| 22. Jornada | 02.04.2022 | Arsenal FC [Sub 18] | - | Southampton FC [Sub 18] | 4:2 | ||||
| 23. Jornada | 09.04.2022 | Southampton FC [Sub 18] | - | Crystal Palace [Sub 18] | 3:2 | ||||
| 12. Jornada | 13.04.2022 | Chelsea FC [Sub 18] | - | Southampton FC [Sub 18] | 0:3 | ||||
| 24. Jornada | 23.04.2022 | Leicester City [Sub 18] | - | Southampton FC [Sub 18] | 0:1 | ||||
| 25. Jornada | 30.04.2022 | Reading FC [Sub 18] | - | Southampton FC [Sub 18] | 1:5 |  |
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| 13. Jornada | 04.05.2022 | Southampton FC [Sub 18] | - | Reading FC [Sub 18] | 3:0 | |
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| 26. Jornada | 07.05.2022 | Southampton FC [Sub 18] | - | Chelsea FC [Sub 18] | 5:2 | |
Inglaterra