| 1. Jornada | 14.08.2021 | Fortuna Sittard | - | FC Twente | 2:1 | ||||
| 3. Jornada | 27.08.2021 | Fortuna Sittard | - | RKC Waalwijk | 2:2 | ||||
| 4. Jornada | 12.09.2021 | Sparta Rotterdam | - | Fortuna Sittard | 3:1 | ||||
| 5. Jornada | 18.09.2021 | sc Heerenveen | - | Fortuna Sittard | 1:0 | ||||
| 6. Jornada | 21.09.2021 | Fortuna Sittard | - | AFC Ajax | 0:5 | ||||
| 9. Jornada | 16.10.2021 | Fortuna Sittard | - | SC Cambuur | 1:0 | ||||
| 10. Jornada | 22.10.2021 | Willem II | - | Fortuna Sittard | 1:1 | ||||
| 11. Jornada | 31.10.2021 | Go Ahead Eagles | - | Fortuna Sittard | 4:3 | ||||
| 13. Jornada | 20.11.2021 | Heracles Almelo | - | Fortuna Sittard | 3:1 | ||||
| 2. Jornada | 02.12.2021 | AZ Alkmaar | - | Fortuna Sittard | 2:1 | ||||
| 15. Jornada | 05.12.2021 | Feyenoord | - | Fortuna Sittard | 5:0 |
Noruega