| 9. Jornada | 05.09.2022 | Cerro Porteño | - | Libertad | 1:0 | ||||
| 11. Jornada | 14.09.2022 | Libertad | - | Tacuary | 2:0 | ||||
| 12. Jornada | 18.09.2022 | Libertad | - | Sportivo Ameliano | 2:1 | ||||
| 14. Jornada | 03.10.2022 | Libertad | - | General Caballero DJLM | 1:0 | ||||
| 13. Jornada | 13.10.2022 | Club Olimpia | - | Libertad | 1:0 | ||||
| 17. Jornada | 18.10.2022 | Sol de América | - | Libertad | 1:1 | ||||
| 18. Jornada | 24.10.2022 | Libertad | - | Club Nacional | 0:1 |  |
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| 19. Jornada | 27.10.2022 | Guaraní | - | Libertad | 1:2 | ||||
| 20. Jornada | 01.11.2022 | Libertad | - | Cerro Porteño | 0:0 |
Paraguay