| 29. Jornada | 29.01.2022 | Mansfield Town | - | Leyton Orient | 2:0 | ||||
| 26. Jornada | 01.02.2022 | Bradford City | - | Leyton Orient | 1:1 | ||||
| 32. Jornada | 12.02.2022 | Leyton Orient | - | Salford City | 0:2 | ||||
| 25. Jornada | 22.02.2022 | Leyton Orient | - | Bristol Rovers | 0:2 | ||||
| 34. Jornada | 26.02.2022 | Leyton Orient | - | Carlisle United | 0:1 | ||||
| 23. Jornada | 01.03.2022 | Colchester United | - | Leyton Orient | 2:2 |  |
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| 35. Jornada | 05.03.2022 | Leyton Orient | - | Stevenage FC | 2:2 |  |
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| 36. Jornada | 12.03.2022 | Hartlepool United | - | Leyton Orient | 0:0 | ||||
| 37. Jornada | 15.03.2022 | Forest Green Rovers | - | Leyton Orient | 1:1 | ||||
| 38. Jornada | 19.03.2022 | Leyton Orient | - | Rochdale AFC | 3:1 | ||||
| 27. Jornada | 29.03.2022 | Oldham Athletic | - | Leyton Orient | 2:0 | ||||
| 40. Jornada | 02.04.2022 | Walsall FC | - | Leyton Orient | 0:2 | ||||
| 43. Jornada | 18.04.2022 | Swindon Town | - | Leyton Orient | 1:2 | ||||
| 44. Jornada | 23.04.2022 | Leyton Orient | - | Northampton Town | 2:4 | ||||
| 45. Jornada | 30.04.2022 | Crawley Town | - | Leyton Orient | 0:2 |
Inglaterra