| 11. Jornada | 14.09.2021 | Banfield II | - | Rosario Central II | 1:3 | ||||
| 12. Jornada | 17.09.2021 | Rosario Central II | - | San Lorenzo II | 1:2 | ||||
| 13. Jornada | 24.09.2021 | Talleres de Córdoba II | - | Rosario Central II | 3:1 | ||||
| 14. Jornada | 01.10.2021 | Rosario Central II | - | Argentinos Juniors II | 0:2 | ||||
| 15. Jornada | 08.10.2021 | Estudiantes II | - | Rosario Central II | 1:1 | ||||
| 16. Jornada | 13.10.2021 | Rosario Central II | - | Patronato de Paraná II | 2:1 | ||||
| 17. Jornada | 18.10.2021 | Platense II | - | Rosario Central II | 0:3 |  |
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| 18. Jornada | 24.10.2021 | Rosario Central II | - | Racing Club II | 1:2 | ||||
| 19. Jornada | 29.10.2021 | Unión de Santa Fe II | - | Rosario Central II | 0:0 | ||||
| 20. Jornada | 05.11.2021 | Defensa y Justicia II | - | Rosario Central II | 1:2 | ||||
| 22. Jornada | 24.11.2021 | Colón de Santa Fe II | - | Rosario Central II | 1:1 | ||||
| 23. Jornada | 28.11.2021 | Rosario Central II | - | River Plate II | 2:0 |  |
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| 24. Jornada | 03.12.2021 | Lanús II | - | Rosario Central II | 2:3 | ||||
| 25. Jornada | 10.12.2021 | Rosario Central II | - | Huracán II | 2:0 |
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