| 14. Jornada | 02.07.2021 | Wexford FC | - | Athlone Town | 4:4 |  |
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| 15. Jornada | 09.07.2021 | UC Dublin | - | Wexford FC | 2:1 |  |
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| 16. Jornada | 16.07.2021 | Wexford FC | - | Cork City | 0:0 | ||||
| 17. Jornada | 30.07.2021 | Wexford FC | - | Galway United | 1:3 | |
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| 18. Jornada | 06.08.2021 | Bray Wanderers | - | Wexford FC | 3:1 | |
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| 19. Jornada | 13.08.2021 | Wexford FC | - | Cabinteely FC | 2:1 | |
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| 20. Jornada | 20.08.2021 | Treaty United | - | Wexford FC | 1:1 | ||||
| 21. Jornada | 03.09.2021 | Shelbourne FC | - | Wexford FC | 4:0 | |
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| 22. Jornada | 10.09.2021 | Wexford FC | - | Cobh Ramblers | 3:1 | |
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| 23. Jornada | 24.09.2021 | Athlone Town | - | Wexford FC | 0:2 | |
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| 24. Jornada | 01.10.2021 | Wexford FC | - | UC Dublin | 2:1 | ||||
| 25. Jornada | 08.10.2021 | Cork City | - | Wexford FC | 4:0 | ||||
| 26. Jornada | 15.10.2021 | Galway United | - | Wexford FC | 2:1 | |
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| 27. Jornada | 29.10.2021 | Wexford FC | - | Bray Wanderers | 4:2 | |
Irlanda