| 17. Jornada | 20.11.2021 | Stevenage FC | - | Colchester United | 1:0 | ||||
| 18. Jornada | 23.11.2021 | Colchester United | - | Exeter City | 3:1 | ||||
| 19. Jornada | 26.11.2021 | Colchester United | - | Newport County | 1:1 | ||||
| 20. Jornada | 08.12.2021 | Bradford City | - | Colchester United | 0:0 | ||||
| 21. Jornada | 11.12.2021 | Walsall FC | - | Colchester United | 3:0 | ||||
| 25. Jornada | 01.01.2022 | Crawley Town | - | Colchester United | 3:1 | ||||
| 16. Jornada | 11.01.2022 | Forest Green Rovers | - | Colchester United | 2:0 | ||||
| 27. Jornada | 15.01.2022 | Colchester United | - | Barrow AFC | 0:2 | ||||
| 24. Jornada | 18.01.2022 | Sutton United | - | Colchester United | 3:2 |
Inglaterra