| 1. Jornada | 07.08.2021 | Bolton Wanderers | - | Milton Keynes Dons | 3:3 |  |
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| 2. Jornada | 14.08.2021 | AFC Wimbledon | - | Bolton Wanderers | 3:3 | |
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| 3. Jornada | 17.08.2021 | Lincoln City | - | Bolton Wanderers | 0:1 | ||||
| 4. Jornada | 21.08.2021 | Bolton Wanderers | - | Oxford United | 2:1 | ||||
| 5. Jornada | 28.08.2021 | Cambridge United | - | Bolton Wanderers | 1:0 | ||||
| 7. Jornada | 11.09.2021 | Ipswich Town | - | Bolton Wanderers | 2:5 | |
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| 8. Jornada | 18.09.2021 | Bolton Wanderers | - | Rotherham United | 0:2 | |
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| 9. Jornada | 25.09.2021 | Sunderland | - | Bolton Wanderers | 1:0 | ||||
| 11. Jornada | 02.10.2021 | Bolton Wanderers | - | Shrewsbury Town | 2:1 | ||||
| 12. Jornada | 09.10.2021 | Sheffield Wednesday | - | Bolton Wanderers | 1:0 | ||||
| 13. Jornada | 16.10.2021 | Bolton Wanderers | - | Wigan Athletic | 0:4 | ||||
| 14. Jornada | 19.10.2021 | Plymouth Argyle | - | Bolton Wanderers | 3:0 | ||||
| 15. Jornada | 23.10.2021 | Bolton Wanderers | - | Gillingham FC | 2:2 | ||||
| 16. Jornada | 30.10.2021 | Portsmouth FC | - | Bolton Wanderers | 1:0 | ||||
| 17. Jornada | 12.11.2021 | Bolton Wanderers | - | Crewe Alexandra | 2:0 | |
Gales