| 1. Jornada | 14.08.2021 | Norwich City [Sub 18] | - | Southampton FC [Sub 18] | 0:2 | ||||
| 2. Jornada | 21.08.2021 | Southampton FC [Sub 18] | - | Birmingham City [Sub 18] | 7:2 | ||||
| 3. Jornada | 28.08.2021 | West Ham United [Sub 18] | - | Southampton FC [Sub 18] | 1:3 | ||||
| 4. Jornada | 11.09.2021 | Southampton FC [Sub 18] | - | Arsenal FC [Sub 18] | 3:3 | ||||
| 5. Jornada | 25.09.2021 | Crystal Palace [Sub 18] | - | Southampton FC [Sub 18] | 1:0 |  |
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| 6. Jornada | 02.10.2021 | Southampton FC [Sub 18] | - | Leicester City [Sub 18] | 0:3 | ||||
| 7. Jornada | 23.10.2021 | West Bromwich Albion [Sub 18] | - | Southampton FC [Sub 18] | 1:5 | ||||
| 8. Jornada | 30.10.2021 | Southampton FC [Sub 18] | - | Brighton & Hove Albion [Sub 18] | 3:2 | ||||
| 9. Jornada | 06.11.2021 | Southampton FC [Sub 18] | - | Aston Villa [Sub 18] | 6:3 | |
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| 10. Jornada | 20.11.2021 | Tottenham Hotspur [Sub 18] | - | Southampton FC [Sub 18] | 0:3 | ||||
| 11. Jornada | 04.12.2021 | Southampton FC [Sub 18] | - | Fulham FC [Sub 18] | 2:0 | ||||
| 15. Jornada | 22.01.2022 | Brighton & Hove Albion [Sub 18] | - | Southampton FC [Sub 18] | 3:4 |
Inglaterra