| 2. Jornada | 23.08.2021 | Nottingham Forest U23 | - | Southampton Sub-21 | 0:0 | ||||
| 4. Jornada | 10.09.2021 | Fulham Sub-21 | - | Southampton Sub-21 | 3:0 | ||||
| 5. Jornada | 19.09.2021 | Southampton Sub-21 | - | Burnley FC U23 | 0:2 | ||||
| 6. Jornada | 27.09.2021 | Birmingham City U23 | - | Southampton Sub-21 | 3:2 | ||||
| 7. Jornada | 01.10.2021 | Southampton Sub-21 | - | Stoke City Sub-21 | 1:1 | ||||
| 9. Jornada | 25.10.2021 | Reading Sub-21 | - | Southampton Sub-21 | 0:1 | ||||
| 11. Jornada | 05.11.2021 | Southampton Sub-21 | - | Newcastle United Sub-21 | 5:0 | ||||
| 12. Jornada | 21.11.2021 | Sunderland Sub-21 | - | Southampton Sub-21 | 3:2 | ||||
| 15. Jornada | 17.12.2021 | Norwich City Sub-21 | - | Southampton Sub-21 | 4:3 | ||||
| 17. Jornada | 17.01.2022 | Southampton Sub-21 | - | Fulham Sub-21 | 2:1 | ||||
| 18. Jornada | 23.01.2022 | Southampton Sub-21 | - | Middlesbrough Sub-21 | 1:0 | ||||
| 20. Jornada | 21.02.2022 | Southampton Sub-21 | - | Birmingham City U23 | 2:3 | ||||
| 16. Jornada | 25.03.2022 | Southampton Sub-21 | - | Wolverhampton Wanderers Sub-21 | 2:4 | ||||
| 24. Jornada | 02.04.2022 | Burnley FC U23 | - | Southampton Sub-21 | 2:1 |
Inglaterra