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| 08.09.2022 | 23:00 | Independiente | - | Aldosivi | 3:0 (2:0) | |
| 09.09.2022 | 01:30 | Argentinos Juniors | - | Rosario Central | 2:1 (1:0) | |
| 01:30 | Unión de Santa Fe | - | Sarmiento de Junín | 1:0 (0:0) | ||
| 20:30 | Barracas Central | - | CA Lanús | 2:0 (1:0) | ||
| 23:00 | Patronato de Paraná | - | Platense | 1:0 (0:0) | ||
| 10.09.2022 | 01:30 | Tigre | - | Huracán | 1:1 (1:1) | |
| 01:30 | Estudiantes | - | Racing Club | 1:0 (1:0) | ||
| 20:30 | Central Córdoba SdE | - | Godoy Cruz | 3:0 (1:0) | ||
| 23:00 | San Lorenzo | - | Atlético Tucumán | 1:1 (1:1) | ||
| 11.09.2022 | 01:30 | Banfield | - | Colón de Santa Fe | 2:1 (0:1) | |
| 18:00 | Arsenal de Sarandí | - | Vélez Sarsfield | 2:2 (1:1) | ||
| 18:00 | Newell's Old Boys | - | Gimnasia de La Plata | 2:0 (2:0) | ||
| 22:00 | Boca Juniors | - | River Plate | 1:0 (0:0) | ||
| 12.09.2022 | 01:00 | Talleres de Córdoba | - | Defensa y Justicia | 1:0 (0:0) |
| » Clasificación | En casa | Fuera de casa | 1.ª vuelta | 2.ª vuelta |
| # | Equipo | P | V | E | D | Goles | DG | Pun. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Atlético Tucumán | 18 | 9 | 7 | 2 | 20:9 | 11 | 34 |
| 2 |
|
Gimnasia de La Plata | 18 | 9 | 6 | 3 | 19:10 | 9 | 33 |
| 3 |
|
Huracán | 18 | 8 | 8 | 2 | 22:13 | 9 | 32 |
| 4 |
|
Boca Juniors | 18 | 10 | 2 | 6 | 24:22 | 2 | 32 |
| 5 |
|
Godoy Cruz | 18 | 9 | 4 | 5 | 21:17 | 4 | 31 |
| 6 |
|
Argentinos Juniors | 18 | 9 | 3 | 6 | 20:16 | 4 | 30 |
| 7 |
|
River Plate | 18 | 8 | 5 | 5 | 27:15 | 12 | 29 |
| 8 |
|
Racing Club | 18 | 7 | 7 | 4 | 24:15 | 9 | 28 |
| 9 |
|
Patronato de Paraná | 18 | 7 | 6 | 5 | 23:19 | 4 | 27 |
| 10 |
|
Unión de Santa Fe | 18 | 7 | 6 | 5 | 23:24 | -1 | 27 |
| 11 |
|
San Lorenzo | 18 | 5 | 11 | 2 | 23:18 | 5 | 26 |
| 12 |
|
Platense | 18 | 6 | 8 | 4 | 17:14 | 3 | 26 |
| 13 |
|
Newell's Old Boys | 18 | 7 | 5 | 6 | 17:16 | 1 | 26 |
| 14 |
|
Estudiantes | 18 | 7 | 5 | 6 | 17:17 | 0 | 26 |
| 15 |
|
Tigre | 18 | 5 | 8 | 5 | 25:23 | 2 | 23 |
| 16 |
|
Barracas Central | 18 | 6 | 5 | 7 | 20:26 | -6 | 23 |
| 17 |
|
Banfield | 18 | 5 | 7 | 6 | 17:18 | -1 | 22 |
| 18 |
|
Sarmiento de Junín | 18 | 6 | 4 | 8 | 18:22 | -4 | 22 |
| 19 |
|
Rosario Central | 18 | 6 | 4 | 8 | 14:18 | -4 | 22 |
| 20 |
|
Central Córdoba SdE | 18 | 6 | 3 | 9 | 22:25 | -3 | 21 |
| 21 |
|
Arsenal de Sarandí | 18 | 3 | 11 | 4 | 18:20 | -2 | 20 |
| 22 |
|
Talleres de Córdoba | 18 | 4 | 7 | 7 | 15:18 | -3 | 19 |
| 23 |
|
Defensa y Justicia | 18 | 4 | 7 | 7 | 14:19 | -5 | 19 |
| 24 |
|
Independiente | 18 | 4 | 6 | 8 | 19:22 | -3 | 18 |
| 25 |
|
Colón de Santa Fe | 18 | 4 | 6 | 8 | 15:22 | -7 | 18 |
| 26 |
|
Vélez Sarsfield | 18 | 1 | 10 | 7 | 19:25 | -6 | 13 |
| 27 |
|
Aldosivi | 18 | 3 | 4 | 11 | 11:28 | -17 | 13 |
| 28 |
|
CA Lanús | 18 | 2 | 5 | 11 | 15:28 | -13 | 11 |
