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| 04.02.2022 | 21:00 | Manchester United | - | Middlesbrough | 7:8 (1:0, 1:1, 1:1) pn. | |
| 05.02.2022 | 13:30 | Chelsea | - | Plymouth Argyle | 2:1 (1:1, 1:1) pró. | |
| 13:30 | Kidderminster Harriers | - | West Ham United | 1:2 (1:0, 1:1) pró. | ||
| 16:00 | Crystal Palace | - | Hartlepool United | 2:0 (2:0) | ||
| 16:00 | Huddersfield Town | - | Barnsley FC | 1:0 (1:0) | ||
| 16:00 | Peterborough United | - | Queens Park Rangers | 2:0 (1:0) | ||
| 16:00 | Southampton | - | Coventry City | 2:1 (0:1, 1:1) pró. | ||
| 16:00 | Everton | - | Brentford FC | 4:1 (1:0) | ||
| 16:00 | Stoke City | - | Wigan Athletic | 2:0 (1:0) | ||
| 16:00 | Manchester City | - | Fulham FC | 4:1 (2:1) | ||
| 16:00 | Wolverhampton Wanderers | - | Norwich City | 0:1 (0:1) | ||
| 18:30 | Cambridge United | - | Luton Town | 0:3 (0:2) | ||
| 21:00 | Tottenham Hotspur | - | Brighton & Hove Albion | 3:1 (2:0) | ||
| 06.02.2022 | 13:00 | Liverpool | - | Cardiff City | 3:1 (0:0) | |
| 17:00 | Nottingham Forest | - | Leicester City | 4:1 (3:1) | ||
| 19:30 | Bournemouth | - | Boreham Wood | 0:1 (0:1) |
