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| 19.12.2021 | 14:30 | ACR Messina | - | Calcio Catania | anu. | |
| 14:30 | Fidelis Andria | - | SS Monopoli 1966 | 1:2 (1:1) | ||
| 14:30 | Paganese Calcio | - | FC Turris | 1:1 (0:0) | ||
| 14:30 | Palermo | - | SSC Bari | 0:0 (0:0) | ||
| 14:30 | Potenza | - | Campobasso | 0:1 (0:1) | ||
| 14:30 | Taranto FC | - | AZ Picerno | 2:0 (1:0) | ||
| 14:30 | US Avellino | - | Foggia Calcio | 2:2 (0:0) | ||
| 14:30 | US Catanzaro | - | Vibonese Calcio | 1:1 (0:0) | ||
| 14:30 | Latina Calcio | - | Monterosi FC | 3:3 (2:0) | ||
| 14:30 | Virtus Francavilla | - | Juve Stabia | 3:0 (2:0) |
| » Clasificación | En casa | Fuera de casa | 1.ª vuelta | 2.ª vuelta |
| # | Equipo | P | V | E | D | Goles | DG | Pun. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
SSC Bari | 18 | 11 | 5 | 2 | 32:14 | 18 | 38 |
| 2 |
|
Palermo | 18 | 9 | 6 | 3 | 25:13 | 12 | 33 |
| 3 |
|
US Catanzaro | 18 | 8 | 7 | 3 | 25:12 | 13 | 31 |
| 4 |
|
US Avellino | 18 | 7 | 10 | 1 | 20:12 | 8 | 31 |
| 5 |
|
SS Monopoli 1966 | 18 | 9 | 4 | 5 | 20:14 | 6 | 31 |
| 6 |
|
FC Turris | 18 | 9 | 3 | 6 | 32:19 | 13 | 30 |
| 7 |
|
Foggia Calcio | 18 | 7 | 8 | 3 | 28:19 | 9 | 29 |
| 8 |
|
Virtus Francavilla | 18 | 9 | 2 | 7 | 21:15 | 6 | 29 |
| 9 |
|
AZ Picerno | 18 | 7 | 5 | 6 | 20:22 | -2 | 26 |
| 10 |
|
Taranto FC | 18 | 6 | 6 | 6 | 18:19 | -1 | 24 |
| 11 |
|
Juve Stabia | 18 | 6 | 7 | 5 | 20:19 | 1 | 23 |
| 12 |
|
Monterosi FC | 18 | 4 | 8 | 6 | 17:24 | -7 | 20 |
| 13 |
|
Campobasso | 18 | 5 | 5 | 8 | 21:30 | -9 | 20 |
| 14 |
|
Latina Calcio | 18 | 5 | 4 | 9 | 20:25 | -5 | 19 |
| 15 |
|
Paganese Calcio | 18 | 5 | 3 | 10 | 19:32 | -13 | 18 |
| 16 |
|
Potenza | 18 | 3 | 6 | 9 | 14:24 | -10 | 15 |
| 17 |
|
Fidelis Andria | 18 | 4 | 3 | 11 | 16:29 | -13 | 15 |
| 18 |
|
Vibonese Calcio | 18 | 2 | 8 | 8 | 13:24 | -11 | 14 |
| 19 |
|
ACR Messina | 18 | 3 | 4 | 11 | 17:32 | -15 | 13 |
| 20 |
|
Calcio Catania | 0 | 0 | 0 | 0 | 0:0 | 0 | 0 |
| Ascenso | |
| Playoff | |
| Permanencia | |
| Descenso |
