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| 06.02.2022 | 14:30 | FC Turris | - | Calcio Catania | anu. | |
| 14:30 | Vibonese Calcio | - | Paganese Calcio | 0:0 (0:0) | ||
| 17:30 | Campobasso | - | Palermo | 2:2 (1:1) | ||
| 17:30 | Foggia Calcio | - | Fidelis Andria | 1:1 (0:0) | ||
| 17:30 | Juve Stabia | - | Latina Calcio | 1:0 (1:0) | ||
| 17:30 | Monterosi FC | - | Taranto FC | 2:1 (1:0) | ||
| 17:30 | AZ Picerno | - | SS Monopoli 1966 | 3:0 (2:0) | ||
| 17:30 | SSC Bari | - | ACR Messina | 1:2 (1:1) | ||
| 17:30 | US Catanzaro | - | US Avellino | 2:0 (0:0) | ||
| 17:30 | Virtus Francavilla | - | Potenza | 4:1 (0:1) |
| » Clasificación | En casa | Fuera de casa | 1.ª vuelta | 2.ª vuelta |
| # | Equipo | P | V | E | D | Goles | DG | Pun. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
SSC Bari | 23 | 15 | 5 | 3 | 39:17 | 22 | 50 |
| 2 |
|
Virtus Francavilla | 24 | 14 | 3 | 7 | 35:19 | 16 | 45 |
| 3 |
|
Palermo | 24 | 11 | 9 | 4 | 36:20 | 16 | 42 |
| 4 |
|
US Avellino | 24 | 10 | 12 | 2 | 31:18 | 13 | 42 |
| 5 |
|
FC Turris | 23 | 12 | 3 | 8 | 40:24 | 16 | 39 |
| 6 |
|
US Catanzaro | 23 | 10 | 9 | 4 | 30:14 | 16 | 39 |
| 7 |
|
SS Monopoli 1966 | 23 | 10 | 6 | 7 | 25:22 | 3 | 36 |
| 8 |
|
Juve Stabia | 24 | 9 | 9 | 6 | 29:25 | 4 | 34 |
| 9 |
|
AZ Picerno | 24 | 9 | 6 | 9 | 25:27 | -2 | 33 |
| 10 |
|
Foggia Calcio | 24 | 7 | 10 | 7 | 34:32 | 2 | 31 |
| 11 |
|
Latina Calcio | 24 | 8 | 6 | 10 | 26:28 | -2 | 30 |
| 12 |
|
Taranto FC | 24 | 7 | 9 | 8 | 25:29 | -4 | 30 |
| 13 |
|
Monterosi FC | 24 | 7 | 9 | 8 | 25:31 | -6 | 30 |
| 14 |
|
Campobasso | 24 | 6 | 8 | 10 | 26:38 | -12 | 26 |
| 15 |
|
ACR Messina | 24 | 6 | 6 | 12 | 27:43 | -16 | 24 |
| 16 |
|
Paganese Calcio | 23 | 5 | 5 | 13 | 23:39 | -16 | 20 |
| 17 |
|
Potenza | 24 | 4 | 7 | 13 | 19:37 | -18 | 19 |
| 18 |
|
Fidelis Andria | 23 | 4 | 6 | 13 | 18:33 | -15 | 18 |
| 19 |
|
Vibonese Calcio | 24 | 2 | 10 | 12 | 15:32 | -17 | 16 |
| 20 |
|
Calcio Catania | 0 | 0 | 0 | 0 | 0:0 | 0 | 0 |
| Ascenso | |
| Playoff | |
| Permanencia | |
| Descenso |
