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| 27.03.2022 | 14:30 | ACR Messina | - | Latina Calcio | 1:0 (1:0) | |
| 14:30 | Foggia Calcio | - | Campobasso | 5:2 (1:2) | ||
| 14:30 | Juve Stabia | - | US Catanzaro | 1:1 (1:0) | ||
| 14:30 | Monterosi FC | - | Vibonese Calcio | 0:0 (0:0) | ||
| 14:30 | Paganese Calcio | - | Palermo | 2:2 (1:1) | ||
| 14:30 | AZ Picerno | - | US Avellino | 0:1 (0:1) | ||
| 14:30 | SS Monopoli 1966 | - | Potenza | 3:1 (0:0) | ||
| 17:30 | SSC Bari | - | Fidelis Andria | 0:0 (0:0) | ||
| 13.04.2022 | Calcio Catania | - | Taranto FC | no jug. | ||
| 14:30 | FC Turris | - | Virtus Francavilla | 1:0 (0:0) |
| » Clasificación | En casa | Fuera de casa | 1.ª vuelta | 2.ª vuelta |
| # | Equipo | P | V | E | D | Goles | DG | Pun. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
SSC Bari | 32 | 20 | 8 | 4 | 50:24 | 26 | 68 |
| 2 |
|
US Catanzaro | 32 | 16 | 10 | 6 | 44:22 | 22 | 58 |
| 3 |
|
US Avellino | 32 | 15 | 13 | 4 | 41:22 | 19 | 58 |
| 4 |
|
Palermo | 33 | 15 | 12 | 6 | 56:33 | 23 | 57 |
| 5 |
|
Virtus Francavilla | 32 | 16 | 6 | 10 | 42:27 | 15 | 54 |
| 6 |
|
SS Monopoli 1966 | 32 | 15 | 7 | 10 | 35:28 | 7 | 52 |
| 7 |
|
Foggia Calcio | 32 | 12 | 13 | 7 | 55:42 | 13 | 49 |
| 8 |
|
FC Turris | 32 | 14 | 4 | 14 | 46:43 | 3 | 46 |
| 9 |
|
Monterosi FC | 32 | 11 | 11 | 10 | 37:36 | 1 | 44 |
| 10 |
|
AZ Picerno | 32 | 12 | 7 | 13 | 33:37 | -4 | 43 |
| 11 |
|
Juve Stabia | 32 | 11 | 10 | 11 | 35:35 | 0 | 41 |
| 12 |
|
Latina Calcio | 33 | 11 | 8 | 14 | 36:41 | -5 | 41 |
| 13 |
|
Campobasso | 32 | 10 | 9 | 13 | 42:53 | -11 | 39 |
| 14 |
|
Taranto FC | 32 | 8 | 12 | 12 | 29:37 | -8 | 36 |
| 15 |
|
ACR Messina | 33 | 9 | 8 | 16 | 38:55 | -17 | 35 |
| 16 |
|
Potenza | 33 | 7 | 11 | 15 | 33:49 | -16 | 32 |
| 17 |
|
Fidelis Andria | 32 | 6 | 10 | 16 | 25:40 | -15 | 28 |
| 18 |
|
Paganese Calcio | 32 | 6 | 8 | 18 | 32:57 | -25 | 26 |
| 19 |
|
Vibonese Calcio | 32 | 3 | 11 | 18 | 21:49 | -28 | 20 |
| 20 |
|
Calcio Catania | 0 | 0 | 0 | 0 | 0:0 | 0 | 0 |
| Ascenso | |
| Playoff | |
| Permanencia | |
| Descenso |
