| 1. Jornada | 14.08.2021 | AFC Ajax | - | NEC Nijmegen | 5:0 | ||||
| 2. Jornada | 22.08.2021 | FC Twente | - | AFC Ajax | 1:1 | ||||
| 3. Jornada | 29.08.2021 | AFC Ajax | - | Vitesse | 5:0 | ||||
| 4. Jornada | 11.09.2021 | PEC Zwolle | - | AFC Ajax | 0:2 | ||||
| 5. Jornada | 18.09.2021 | AFC Ajax | - | SC Cambuur | 9:0 |  |
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| 7. Jornada | 25.09.2021 | AFC Ajax | - | FC Groningen | 3:0 | ||||
| 8. Jornada | 03.10.2021 | AFC Ajax | - | FC Utrecht | 0:1 | ||||
| 9. Jornada | 16.10.2021 | sc Heerenveen | - | AFC Ajax | 0:2 | |
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| 10. Jornada | 24.10.2021 | AFC Ajax | - | PSV | 5:0 | ||||
| 11. Jornada | 30.10.2021 | Heracles Almelo | - | AFC Ajax | 0:0 | ||||
| 12. Jornada | 07.11.2021 | AFC Ajax | - | Go Ahead Eagles | 0:0 | ||||
| 13. Jornada | 21.11.2021 | RKC Waalwijk | - | AFC Ajax | 0:5 | ||||
| 14. Jornada | 28.11.2021 | Sparta Rotterdam | - | AFC Ajax | 0:1 |  |
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| 15. Jornada | 02.12.2021 | AFC Ajax | - | Willem II | 5:0 | ||||
| 18. Jornada | 22.12.2021 | AFC Ajax | - | Fortuna Sittard | 5:0 |
Brasil
