| 1. Jornada | 29.08.2021 | Fidelis Andria | - | Juve Stabia | 1:1 |  |
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| 2. Jornada | 04.09.2021 | Calcio Catania | - | Fidelis Andria | anu. | |
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| 3. Jornada | 12.09.2021 | Fidelis Andria | - | Virtus Francavilla | 0:1 | ||||
| 4. Jornada | 19.09.2021 | Fidelis Andria | - | Vibonese Calcio | 1:1 |  |
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| 5. Jornada | 26.09.2021 | Campobasso | - | Fidelis Andria | 1:3 | ||||
| 6. Jornada | 29.09.2021 | Fidelis Andria | - | Foggia Calcio | 0:3 | ||||
| 9. Jornada | 17.10.2021 | Fidelis Andria | - | US Avellino | 1:1 | ||||
| 10. Jornada | 20.10.2021 | Taranto FC | - | Fidelis Andria | 2:1 | ||||
| 11. Jornada | 24.10.2021 | Fidelis Andria | - | FC Turris | 1:0 | ||||
| 12. Jornada | 30.10.2021 | Latina Calcio | - | Fidelis Andria | 1:0 | ||||
| 13. Jornada | 07.11.2021 | Fidelis Andria | - | Palermo | 0:2 | ||||
| 14. Jornada | 14.11.2021 | Paganese Calcio | - | Fidelis Andria | 0:1 | ||||
| 15. Jornada | 21.11.2021 | Fidelis Andria | - | SSC Bari | 0:3 | |
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| 16. Jornada | 28.11.2021 | ACR Messina | - | Fidelis Andria | 2:3 | ||||
| 17. Jornada | 05.12.2021 | Fidelis Andria | - | AZ Picerno | 2:3 | ||||
| 19. Jornada | 19.12.2021 | Fidelis Andria | - | SS Monopoli 1966 | 1:2 | |
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| 20. Jornada | 22.12.2021 | Juve Stabia | - | Fidelis Andria | 1:1 |
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