| 4. Jornada | 15.08.2021 | SV Zulte Waregem | - | Club Brugge KV | 0:4 | ||||
| 6. Jornada | 29.08.2021 | Gante | - | Club Brugge KV | 6:1 | ||||
| 8. Jornada | 18.09.2021 | Sporting Charleroi | - | Club Brugge KV | 0:1 | ||||
| 10. Jornada | 03.10.2021 | RSC Anderlecht | - | Club Brugge KV | 1:1 | ||||
| 11. Jornada | 15.10.2021 | Club Brugge KV | - | KV Kortrijk | 2:0 | ||||
| 12. Jornada | 24.10.2021 | Royal Antwerp FC | - | Club Brugge KV | 1:1 | ||||
| 13. Jornada | 30.10.2021 | Sint-Truidense VV | - | Club Brugge KV | 1:2 | ||||
| 14. Jornada | 07.11.2021 | Club Brugge KV | - | Standard Liège | 2:2 | ||||
| 16. Jornada | 28.11.2021 | KRC Genk | - | Club Brugge KV | 2:3 |  |
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| 18. Jornada | 12.12.2021 | Club Brugge KV | - | SV Zulte Waregem | 3:0 | ||||
| 19. Jornada | 15.12.2021 | Oud-Heverlee Leuven | - | Club Brugge KV | 1:4 | ||||
| 23. Jornada | 23.01.2022 | Standard Liège | - | Club Brugge KV | 2:2 |
Bélgica