| 1. Jornada | 11.09.2021 | Panetolikos | - | Asteras Tripolis | 0:0 | ||||
| 2. Jornada | 19.09.2021 | Atromitos | - | Panetolikos | 1:2 | ||||
| 3. Jornada | 22.09.2021 | Panetolikos | - | PAOK Saloniki | 1:2 | ||||
| 4. Jornada | 26.09.2021 | Lamia | - | Panetolikos | 2:2 |  |
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| 5. Jornada | 03.10.2021 | Panetolikos | - | AEK Athen | 1:3 | ||||
| 6. Jornada | 17.10.2021 | Panetolikos | - | OFI Heraklion | 1:2 | ||||
| 7. Jornada | 24.10.2021 | Aris Saloniki | - | Panetolikos | 5:1 |
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