| 1. Jornada | 19.09.2021 | UE Santa Coloma | - | FC Santa Coloma | 2:1 |  |
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| 2. Jornada | 26.09.2021 | FC Santa Coloma | - | UE Engordany | 1:1 | ||||
| 3. Jornada | 03.10.2021 | CE Carroi | - | FC Santa Coloma | 2:5 | |
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| 4. Jornada | 17.10.2021 | FC Santa Coloma | - | FC Ordino | 3:2 |  |
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| 6. Jornada | 31.10.2021 | Inter Club d'Escaldes | - | FC Santa Coloma | 1:1 | |
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| 7. Jornada | 07.11.2021 | FC Santa Coloma | - | Atlétic Escaldes | 1:3 | |
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| 9. Jornada | 28.11.2021 | UE Engordany | - | FC Santa Coloma | 2:4 | |
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| 8. Jornada | 26.01.2022 | FC Santa Coloma | - | UE Santa Coloma | 3:1 | ||||
| 13. Jornada | 30.01.2022 | FC Santa Coloma | - | Inter Club d'Escaldes | 3:2 | ||||
| 15. Jornada | 13.02.2022 | UE Santa Coloma | - | FC Santa Coloma | 1:1 | ||||
| 17. Jornada | 27.02.2022 | CE Carroi | - | FC Santa Coloma | 0:5 | |
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| 18. Jornada | 06.03.2022 | FC Santa Coloma | - | FC Ordino | 2:1 | |
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| 19. Jornada | 13.03.2022 | FC Santa Coloma | - | UE Sant Julià | 2:0 | ||||
| 20. Jornada | 20.03.2022 | Inter Club d'Escaldes | - | FC Santa Coloma | 1:2 | |
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| 21. Jornada | 03.04.2022 | FC Santa Coloma | - | Atlétic Escaldes | 1:1 |
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