| 5. Jornada | 18.09.2021 | Willem II | - | FC Groningen | 2:1 | ||||
| 8. Jornada | 02.10.2021 | Heracles Almelo | - | Willem II | 3:2 | ||||
| 12. Jornada | 06.11.2021 | Willem II | - | Sparta Rotterdam | 0:3 | ||||
| 13. Jornada | 21.11.2021 | sc Heerenveen | - | Willem II | 2:1 | ||||
| 14. Jornada | 27.11.2021 | Willem II | - | Go Ahead Eagles | 0:1 | ||||
| 15. Jornada | 02.12.2021 | AFC Ajax | - | Willem II | 5:0 |  |
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| 16. Jornada | 10.12.2021 | Willem II | - | SC Cambuur | 1:3 | ||||
| 18. Jornada | 22.12.2021 | Willem II | - | NEC Nijmegen | 0:1 |
Alemania