| 3. Jornada | 12.09.2021 | AC Reggiana 1919 | - | AS Gubbio | 0:0 |  |
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| 4. Jornada | 18.09.2021 | AS Gubbio | - | Virtus Entella | 3:1 | ||||
| 6. Jornada | 28.09.2021 | AS Gubbio | - | Delfino Pescara | 2:2 | ||||
| 7. Jornada | 03.10.2021 | Olbia Calcio | - | AS Gubbio | 1:0 | ||||
| 8. Jornada | 09.10.2021 | AS Gubbio | - | US Pontedera | 3:0 | ||||
| 12. Jornada | 01.11.2021 | AS Gubbio | - | ACN Siena 1904 | 1:2 | ||||
| 23. Jornada | 22.01.2022 | Virtus Entella | - | AS Gubbio | 4:0 | ||||
| 25. Jornada | 06.02.2022 | Delfino Pescara | - | AS Gubbio | 3:1 | ||||
| 26. Jornada | 13.02.2022 | AS Gubbio | - | Olbia Calcio | 1:1 | ||||
| 29. Jornada | 27.02.2022 | Carrarese Calcio | - | AS Gubbio | 1:0 | |
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| 30. Jornada | 06.03.2022 | AS Gubbio | - | Vis Pesaro | 3:0 | ||||
| 31. Jornada | 12.03.2022 | ACN Siena 1904 | - | AS Gubbio | 1:2 | ||||
| 32. Jornada | 15.03.2022 | AS Gubbio | - | Imolese Calcio | 2:1 | ||||
| 33. Jornada | 19.03.2022 | Lucchese | - | AS Gubbio | 2:2 |
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