| 1. Jornada | 26.07.2021 | Club Tijuana | - | UANL Tigres | 1:2 | ||||
| 2. Jornada | 01.08.2021 | Club León | - | Club Tijuana | 2:1 | ||||
| 3. Jornada | 07.08.2021 | Club Tijuana | - | Deportivo Toluca | 0:2 |  |
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| 4. Jornada | 14.08.2021 | FC Juárez | - | Club Tijuana | 1:1 |  |
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| 6. Jornada | 23.08.2021 | CF América | - | Club Tijuana | 2:0 | ||||
| 7. Jornada | 28.08.2021 | Club Tijuana | - | CF Monterrey | 2:2 | ||||
| 8. Jornada | 11.09.2021 | Club Tijuana | - | Santos Laguna | 2:1 | ||||
| 9. Jornada | 17.09.2021 | Atlético San Luis | - | Club Tijuana | 4:1 | |
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| 10. Jornada | 25.09.2021 | Club Tijuana | - | Mazatlán FC | 0:0 | ||||
| 11. Jornada | 29.09.2021 | Club Necaxa | - | Club Tijuana | 3:0 | ||||
| 12. Jornada | 04.10.2021 | Club Tijuana | - | Cruz Azul | 0:1 | |
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| 13. Jornada | 15.10.2021 | Gallos Blancos | - | Club Tijuana | 1:1 | ||||
| 14. Jornada | 21.10.2021 | Club Tijuana | - | Deportivo Guadalajara | 0:0 | ||||
| 15. Jornada | 24.10.2021 | Pumas UNAM | - | Club Tijuana | 3:1 | ||||
| 16. Jornada | 29.10.2021 | Atlas Guadalajara | - | Club Tijuana | 0:2 | ||||
| 17. Jornada | 07.11.2021 | Club Tijuana | - | CF Pachuca | 3:2 |
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