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| 06.08.2022 | 00:00 | Gimnasia de La Plata | - | Godoy Cruz | 2:0 (0:0) | |
| 02:30 | Banfield | - | Patronato de Paraná | 0:0 (0:0) | ||
| 02:30 | Sarmiento de Junín | - | CA Lanús | 2:1 (2:0) | ||
| 18:00 | Arsenal de Sarandí | - | Atlético Tucumán | 3:1 (1:1) | ||
| 20:00 | Barracas Central | - | Racing Club | 0:0 (0:0) | ||
| 23:00 | Talleres de Córdoba | - | Argentinos Juniors | 2:0 (1:0) | ||
| 23:00 | Unión de Santa Fe | - | Vélez Sarsfield | 2:1 (0:1) | ||
| 07.08.2022 | 02:00 | Boca Juniors | - | Platense | 2:1 (2:0) | |
| 18:00 | Aldosivi | - | Huracán | 0:1 (0:0) | ||
| 20:00 | San Lorenzo | - | Estudiantes | 0:0 (0:0) | ||
| 22:30 | Independiente | - | River Plate | 0:1 (0:0) | ||
| 08.08.2022 | 01:00 | Newell's Old Boys | - | Colón de Santa Fe | 0:0 (0:0) | |
| 16:00 | Central Córdoba SdE | - | Defensa y Justicia | 1:0 (0:0) | ||
| 09.08.2022 | 01:00 | Tigre | - | Rosario Central | 3:1 (2:1) |
| » Clasificación | En casa | Fuera de casa | 1.ª vuelta | 2.ª vuelta |
| # | Equipo | P | V | E | D | Goles | DG | Pun. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Atlético Tucumán | 12 | 7 | 4 | 1 | 13:6 | 7 | 25 |
| 2 |
|
Gimnasia de La Plata | 12 | 7 | 3 | 2 | 13:6 | 7 | 24 |
| 3 |
|
Unión de Santa Fe | 12 | 6 | 4 | 2 | 22:19 | 3 | 22 |
| 4 |
|
Racing Club | 12 | 5 | 5 | 2 | 19:11 | 8 | 20 |
| 5 |
|
Argentinos Juniors | 12 | 6 | 2 | 4 | 15:12 | 3 | 20 |
| 6 |
|
Huracán | 12 | 5 | 5 | 2 | 12:9 | 3 | 20 |
| 7 |
|
River Plate | 12 | 5 | 3 | 4 | 17:12 | 5 | 18 |
| 8 |
|
Patronato de Paraná | 12 | 5 | 3 | 4 | 16:13 | 3 | 18 |
| 9 |
|
Godoy Cruz | 12 | 5 | 3 | 4 | 13:11 | 2 | 18 |
| 10 |
|
Platense | 12 | 4 | 6 | 2 | 12:10 | 2 | 18 |
| 11 |
|
Boca Juniors | 12 | 6 | 0 | 6 | 18:20 | -2 | 18 |
| 12 |
|
San Lorenzo | 12 | 3 | 8 | 1 | 15:12 | 3 | 17 |
| 13 |
|
Newell's Old Boys | 12 | 4 | 5 | 3 | 10:9 | 1 | 17 |
| 14 |
|
Sarmiento de Junín | 12 | 5 | 2 | 5 | 13:13 | 0 | 17 |
| 15 |
|
Tigre | 12 | 4 | 4 | 4 | 20:18 | 2 | 16 |
| 16 |
|
Arsenal de Sarandí | 12 | 3 | 7 | 2 | 14:14 | 0 | 16 |
| 17 |
|
Banfield | 12 | 3 | 6 | 3 | 12:10 | 2 | 15 |
| 18 |
|
Defensa y Justicia | 12 | 3 | 5 | 4 | 11:13 | -2 | 14 |
| 19 |
|
Colón de Santa Fe | 12 | 3 | 5 | 4 | 10:12 | -2 | 14 |
| 20 |
|
Central Córdoba SdE | 12 | 4 | 2 | 6 | 14:17 | -3 | 14 |
| 21 |
|
Barracas Central | 12 | 3 | 5 | 4 | 13:16 | -3 | 14 |
| 22 |
|
Rosario Central | 12 | 4 | 2 | 6 | 8:13 | -5 | 14 |
| 23 |
|
Talleres de Córdoba | 12 | 3 | 4 | 5 | 10:12 | -2 | 13 |
| 24 |
|
Estudiantes | 12 | 3 | 4 | 5 | 13:16 | -3 | 13 |
| 25 |
|
Independiente | 12 | 3 | 2 | 7 | 11:15 | -4 | 11 |
| 26 |
|
Vélez Sarsfield | 12 | 1 | 6 | 5 | 12:16 | -4 | 9 |
| 27 |
|
Aldosivi | 12 | 2 | 2 | 8 | 7:19 | -12 | 8 |
| 28 |
|
CA Lanús | 12 | 1 | 3 | 8 | 10:19 | -9 | 6 |
