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| 16.04.2022 | 10:30 | Nápoles | - | Cagliari Calcio | 1:2 (0:1) | |
| 10:30 | US Lecce | - | Juventus | 1:1 (0:1) | ||
| 12:30 | Génova | - | Inter | 0:4 (0:0) | ||
| 12:30 | Delfino Pescara | - | Atalanta | 2:3 (1:1) | ||
| 14:30 | Torino | - | Fiorentina | 0:1 (0:0) | ||
| 15:00 | Empoli | - | Bolonia | 2:1 (1:1) | ||
| 15:00 | SPAL 2013 Ferrara | - | Roma | 0:1 (0:1) | ||
| 16:30 | Milan | - | Sampdoria | 1:4 (0:1) | ||
| 17:00 | Sassuolo | - | Hellas Verona | 1:2 (0:1) |
| » Clasificación | En casa | Fuera de casa | 1.ª vuelta | 2.ª vuelta | 1.ª parte | 2.ª parte |
| # | Equipo | P | V | E | D | Goles | DG | Pun. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Roma | 29 | 18 | 7 | 4 | 54:27 | 27 | 61 |
| 2 |
|
Cagliari Calcio | 29 | 16 | 6 | 7 | 50:36 | 14 | 54 |
| 3 |
|
Inter | 29 | 15 | 8 | 6 | 52:30 | 22 | 53 |
| 4 |
|
Atalanta | 29 | 15 | 6 | 8 | 54:39 | 15 | 51 |
| 5 |
|
Fiorentina | 29 | 14 | 6 | 9 | 41:38 | 3 | 48 |
| 6 |
|
Juventus | 29 | 14 | 5 | 10 | 54:41 | 13 | 47 |
| 7 |
|
Sampdoria | 29 | 13 | 5 | 11 | 53:44 | 9 | 44 |
| 8 |
|
Sassuolo | 29 | 11 | 7 | 11 | 38:28 | 10 | 40 |
| 9 |
|
Torino | 29 | 10 | 10 | 9 | 38:37 | 1 | 40 |
| 10 |
|
Empoli | 29 | 10 | 9 | 10 | 37:36 | 1 | 39 |
| 11 |
|
Milan | 29 | 12 | 3 | 14 | 46:49 | -3 | 39 |
| 12 |
|
Hellas Verona | 29 | 11 | 4 | 14 | 37:45 | -8 | 37 |
| 13 |
|
Bolonia | 29 | 11 | 3 | 15 | 39:45 | -6 | 36 |
| 14 |
|
Génova | 29 | 9 | 8 | 12 | 34:34 | 0 | 35 |
| 15 |
|
US Lecce | 29 | 8 | 10 | 11 | 33:41 | -8 | 34 |
| 16 |
|
Nápoles | 29 | 9 | 6 | 14 | 34:48 | -14 | 33 |
| 17 |
|
SPAL 2013 Ferrara | 29 | 5 | 8 | 16 | 29:63 | -34 | 23 |
| 18 |
|
Delfino Pescara | 29 | 3 | 3 | 23 | 26:68 | -42 | 12 |
| Playoff | |
| Próxima ronda | |
| Permanencia | |
| Descenso |
