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| 19.02.2022 | 14:30 | Calcio Catania | - | Virtus Francavilla | anu. | |
| 14:30 | Paganese Calcio | - | Monterosi FC | 0:3 (0:1) | ||
| 14:30 | Palermo | - | FC Turris | 5:0 (2:0) | ||
| 14:30 | AZ Picerno | - | SS Juve Stabia | 1:0 (0:0) | ||
| 14:30 | Taranto FC | - | US Catanzaro | 0:1 (0:0) | ||
| 17:30 | ACR Messina | - | Potenza | 2:0 (1:0) | ||
| 17:30 | SS Monopoli 1966 | - | Foggia Calcio | 0:1 (0:1) | ||
| 17:30 | SSC Bari | - | Campobasso | 2:3 (0:1) | ||
| 17:30 | US Avellino | - | Fidelis Andria | 2:0 (0:0) | ||
| 17:30 | Latina Calcio | - | Vibonese Calcio | 3:2 (2:0) |
| » Clasificación | En casa | Fuera de casa | 1.ª vuelta | 2.ª vuelta |
| # | Equipo | P | V | E | D | Goles | DG | Pun. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
SSC Bari | 26 | 16 | 6 | 4 | 42:20 | 22 | 54 |
| 2 |
|
Virtus Francavilla | 26 | 15 | 4 | 7 | 36:19 | 17 | 49 |
| 3 |
|
Palermo | 27 | 13 | 9 | 5 | 45:25 | 20 | 48 |
| 4 |
|
US Catanzaro | 26 | 13 | 9 | 4 | 33:14 | 19 | 48 |
| 5 |
|
US Avellino | 27 | 12 | 12 | 3 | 35:19 | 16 | 48 |
| 6 |
|
FC Turris | 26 | 12 | 3 | 11 | 41:33 | 8 | 39 |
| 7 |
|
Latina Calcio | 27 | 11 | 6 | 10 | 34:31 | 3 | 39 |
| 8 |
|
Foggia Calcio | 27 | 9 | 11 | 7 | 40:34 | 6 | 38 |
| 9 |
|
SS Monopoli 1966 | 26 | 10 | 7 | 9 | 25:24 | 1 | 37 |
| 10 |
|
Monterosi FC | 27 | 9 | 9 | 9 | 31:34 | -3 | 36 |
| 11 |
|
AZ Picerno | 26 | 10 | 6 | 10 | 26:29 | -3 | 36 |
| 12 |
|
SS Juve Stabia | 26 | 9 | 9 | 8 | 30:29 | 1 | 34 |
| 13 |
|
Campobasso | 27 | 8 | 8 | 11 | 31:42 | -11 | 32 |
| 14 |
|
Taranto FC | 27 | 7 | 10 | 10 | 25:31 | -6 | 31 |
| 15 |
|
ACR Messina | 27 | 7 | 7 | 13 | 31:47 | -16 | 28 |
| 16 |
|
Potenza | 27 | 5 | 8 | 14 | 24:42 | -18 | 23 |
| 17 |
|
Paganese Calcio | 26 | 6 | 5 | 15 | 25:44 | -19 | 23 |
| 18 |
|
Fidelis Andria | 26 | 4 | 7 | 15 | 19:37 | -18 | 19 |
| 19 |
|
Vibonese Calcio | 27 | 3 | 10 | 14 | 20:39 | -19 | 19 |
| 20 |
|
Calcio Catania | 0 | 0 | 0 | 0 | 0:0 | 0 | 0 |
| Ascenso | |
| Playoff | |
| Permanencia | |
| Descenso |
