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| 19.03.2022 | 11:00 | Milan | - | Hellas Verona | 2:0 (1:0) | |
| 13:00 | Roma | - | Inter | 1:1 (1:1) | ||
| 15:00 | Atalanta | - | Fiorentina | 2:0 (1:0) | ||
| 17:00 | Torino | - | SPAL 2013 Ferrara | 1:1 (1:0) | ||
| 20.03.2022 | 10:30 | Génova | - | Juventus | 1:2 (0:1) | |
| 11:00 | Cagliari Calcio | - | Bolonia | 2:1 (1:1) | ||
| 12:30 | Sassuolo | - | Nápoles | 1:1 (1:0) | ||
| 13:00 | Empoli | - | US Lecce | 2:1 (1:0) | ||
| 15:00 | Delfino Pescara | - | Sampdoria | 1:2 (1:2) |
| » Clasificación | En casa | Fuera de casa | 1.ª vuelta | 2.ª vuelta | 1.ª parte | 2.ª parte |
| # | Equipo | P | V | E | D | Goles | DG | Pun. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Roma | 25 | 15 | 7 | 3 | 46:24 | 22 | 52 |
| 2 |
|
Cagliari Calcio | 25 | 13 | 6 | 6 | 40:29 | 11 | 45 |
| 3 |
|
Inter | 25 | 12 | 7 | 6 | 41:28 | 13 | 43 |
| 4 |
|
Fiorentina | 25 | 13 | 4 | 8 | 37:33 | 4 | 43 |
| 5 |
|
Sampdoria | 25 | 12 | 5 | 8 | 49:37 | 12 | 41 |
| 6 |
|
Juventus | 25 | 12 | 4 | 9 | 44:35 | 9 | 40 |
| 7 |
|
Atalanta | 25 | 11 | 6 | 8 | 41:32 | 9 | 39 |
| 8 |
|
Sassuolo | 25 | 10 | 7 | 8 | 30:20 | 10 | 37 |
| 9 |
|
Torino | 25 | 9 | 9 | 7 | 35:33 | 2 | 36 |
| 10 |
|
Milan | 25 | 11 | 3 | 11 | 38:37 | 1 | 36 |
| 11 |
|
Empoli | 25 | 8 | 8 | 9 | 31:31 | 0 | 32 |
| 12 |
|
Nápoles | 25 | 9 | 4 | 12 | 31:43 | -12 | 31 |
| 13 |
|
Génova | 25 | 8 | 6 | 11 | 31:28 | 3 | 30 |
| 14 |
|
Bolonia | 25 | 9 | 3 | 13 | 33:39 | -6 | 30 |
| 15 |
|
Hellas Verona | 25 | 9 | 3 | 13 | 31:40 | -9 | 30 |
| 16 |
|
US Lecce | 25 | 6 | 9 | 10 | 28:37 | -9 | 27 |
| 17 |
|
SPAL 2013 Ferrara | 25 | 4 | 8 | 13 | 25:53 | -28 | 20 |
| 18 |
|
Delfino Pescara | 25 | 3 | 3 | 19 | 22:54 | -32 | 12 |
| Playoff | |
| Próxima ronda | |
| Permanencia | |
| Descenso |
