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| 02.04.2022 | 10:30 | Cagliari Calcio | - | Atalanta | 3:4 (0:2) | |
| 11:00 | Bolonia | - | Roma | 3:0 (2:0) | ||
| 13:00 | Hellas Verona | - | Delfino Pescara | 2:1 (1:0) | ||
| 13:00 | Juventus | - | Milan | 4:1 (2:0) | ||
| 15:00 | Fiorentina | - | Empoli | 1:1 (0:1) | ||
| 17:00 | Sampdoria | - | Génova | 0:1 (0:0) | ||
| 03.04.2022 | 11:00 | SPAL 2013 Ferrara | - | US Lecce | 2:0 (2:0) | |
| 13:00 | Nápoles | - | Torino | 1:1 (0:0) | ||
| 04.04.2022 | 15:00 | Inter | - | Sassuolo | 2:1 (1:1) |
| » Clasificación | En casa | Fuera de casa | 1.ª vuelta | 2.ª vuelta | 1.ª parte | 2.ª parte |
| # | Equipo | P | V | E | D | Goles | DG | Pun. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Roma | 26 | 15 | 7 | 4 | 46:27 | 19 | 52 |
| 2 |
|
Inter | 26 | 13 | 7 | 6 | 43:29 | 14 | 46 |
| 3 |
|
Cagliari Calcio | 26 | 13 | 6 | 7 | 43:33 | 10 | 45 |
| 4 |
|
Fiorentina | 26 | 13 | 5 | 8 | 38:34 | 4 | 44 |
| 5 |
|
Juventus | 26 | 13 | 4 | 9 | 48:36 | 12 | 43 |
| 6 |
|
Atalanta | 26 | 12 | 6 | 8 | 45:35 | 10 | 42 |
| 7 |
|
Sampdoria | 26 | 12 | 5 | 9 | 49:38 | 11 | 41 |
| 8 |
|
Sassuolo | 26 | 10 | 7 | 9 | 31:22 | 9 | 37 |
| 9 |
|
Torino | 26 | 9 | 10 | 7 | 36:34 | 2 | 37 |
| 10 |
|
Milan | 26 | 11 | 3 | 12 | 39:41 | -2 | 36 |
| 11 |
|
Génova | 26 | 9 | 6 | 11 | 32:28 | 4 | 33 |
| 12 |
|
Empoli | 26 | 8 | 9 | 9 | 32:32 | 0 | 33 |
| 13 |
|
Bolonia | 26 | 10 | 3 | 13 | 36:39 | -3 | 33 |
| 14 |
|
Hellas Verona | 26 | 10 | 3 | 13 | 33:41 | -8 | 33 |
| 15 |
|
Nápoles | 26 | 9 | 5 | 12 | 32:44 | -12 | 32 |
| 16 |
|
US Lecce | 26 | 6 | 9 | 11 | 28:39 | -11 | 27 |
| 17 |
|
SPAL 2013 Ferrara | 26 | 5 | 8 | 13 | 27:53 | -26 | 23 |
| 18 |
|
Delfino Pescara | 26 | 3 | 3 | 20 | 23:56 | -33 | 12 |
| Playoff | |
| Próxima ronda | |
| Permanencia | |
| Descenso |
