| 1. Jornada | 25.07.2021 | MFK Zemplín Michalovce | - | FC DAC 1904 | 4:1 | ||||
| 2. Jornada | 01.08.2021 | FC DAC 1904 | - | Tatran Liptovský Mikuláš | 3:1 |  |
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| 3. Jornada | 08.08.2021 | ŠKF Sereď | - | FC DAC 1904 | 1:0 | ||||
| 4. Jornada | 14.08.2021 | FK Senica | - | FC DAC 1904 | 1:1 | ||||
| 6. Jornada | 27.08.2021 | FK Pohronie | - | FC DAC 1904 | 0:3 | |
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| 7. Jornada | 12.09.2021 | FC DAC 1904 | - | Slovan Bratislava | 1:1 | |
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| 8. Jornada | 18.09.2021 | MFK Ružomberok | - | FC DAC 1904 | 1:2 | ||||
| 9. Jornada | 26.09.2021 | FC DAC 1904 | - | Spartak Trnava | 0:3 | |
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| 10. Jornada | 01.10.2021 | FC DAC 1904 | - | Zlaté Moravce | 4:2 | ||||
| 11. Jornada | 16.10.2021 | MŠK Žilina | - | FC DAC 1904 | 0:2 | ||||
| 12. Jornada | 24.10.2021 | FC DAC 1904 | - | MFK Zemplín Michalovce | 1:0 | ||||
| 13. Jornada | 30.10.2021 | Tatran Liptovský Mikuláš | - | FC DAC 1904 | 1:0 | |
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| 14. Jornada | 06.11.2021 | FC DAC 1904 | - | ŠKF Sereď | 1:3 | ||||
| 15. Jornada | 20.11.2021 | FC DAC 1904 | - | FK Senica | 1:0 | ||||
| 17. Jornada | 04.12.2021 | FC DAC 1904 | - | FK Pohronie | 2:0 | ||||
| 18. Jornada | 12.12.2021 | Slovan Bratislava | - | FC DAC 1904 | 0:0 | ||||
| 19. Jornada | 17.12.2021 | FC DAC 1904 | - | MFK Ružomberok | 0:0 |
Hungría