| 1. Jornada | 31.08.1980 | BSG Chemie Wolfen | - | BSG Chemie Zeitz | 1:1 |  |
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| 2. Jornada | 07.09.1980 | BSG Chemie Zeitz | - | BSG Stahl Blankenburg | 0:4 | ||||
| 3. Jornada | 14.09.1980 | BSG MK Sangerhausen | - | BSG Chemie Zeitz | 3:1 | ||||
| 4. Jornada | 21.09.1980 | BSG Chemie Zeitz | - | Chemie Schönebeck | 3:1 | ||||
| 12. Jornada | 30.11.1980 | BSG Chemie Zeitz | - | BSG Chemie Wolfen | 3:2 | ||||
| 13. Jornada | 07.12.1980 | BSG Stahl Blankenburg | - | BSG Chemie Zeitz | 2:1 | ||||
| 14. Jornada | 13.12.1980 | BSG Chemie Zeitz | - | BSG MK Sangerhausen | 3:2 | |
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| 17. Jornada | 15.03.1981 | ASG Vorwärts Dessau | - | BSG Chemie Zeitz | 3:2 | ||||
| 18. Jornada | 22.03.1981 | BSG Chemie Zeitz | - | BSG Chemie Leipzig | 1:1 | ||||
| 19. Jornada | 29.03.1981 | BSG Stahl Thale | - | BSG Chemie Zeitz | 2:2 | |
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| 20. Jornada | 04.04.1981 | BSG Chemie Zeitz | - | SG Dynamo Eisleben | 1:0 | ||||
| 21. Jornada | 12.04.1981 | BSG Chemie Buna Schkopau | - | BSG Chemie Zeitz | 3:0 | ||||
| 22. Jornada | 17.04.1981 | BSG Chemie Zeitz | - | BSG Lokomotive Stendal | 2:1 |
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