| 1. Jornada | 15.08.2021 | Schalke II | - | Colonia | 1:2 |  |
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| 2. Jornada | 20.08.2021 | Colonia | - | SV Lippstadt 08 | 3:1 | ||||
| 3. Jornada | 25.08.2021 | Rot-Weiß Oberhausen | - | Colonia | 1:0 | ||||
| 4. Jornada | 28.08.2021 | Colonia | - | KFC Uerdingen 05 | 8:2 | ||||
| 6. Jornada | 10.09.2021 | Colonia | - | Bonner SC | 3:2 | ||||
| 9. Jornada | 25.09.2021 | Colonia | - | Sportfreunde Lotte | 4:0 | ||||
| 5. Jornada | 28.09.2021 | SC Wiedenbrück | - | Colonia | 2:0 | ||||
| 10. Jornada | 01.10.2021 | FC Wegberg-Beeck | - | Colonia | 0:1 | ||||
| 12. Jornada | 15.10.2021 | Rot Weiss Ahlen | - | Colonia | 2:6 | ||||
| 29. Jornada | 12.03.2022 | Colonia | - | FC Wegberg-Beeck | 4:1 | ||||
| 31. Jornada | 26.03.2022 | Colonia | - | Rot Weiss Ahlen | 6:1 | ||||
| 32. Jornada | 01.04.2022 | Rot-Weiss Essen | - | Colonia | 2:0 | ||||
| 26. Jornada | 20.04.2022 | Alemannia Aachen | - | Colonia | 1:1 | ||||
| 35. Jornada | 23.04.2022 | Colonia | - | Fortuna Köln | 2:2 | ||||
| 36. Jornada | 29.04.2022 | Fortuna Düsseldorf II | - | Colonia | 0:1 | ||||
| 37. Jornada | 07.05.2022 | Colonia | - | VfB Homberg | 2:1 | ||||
| 38. Jornada | 14.05.2022 | Preußen Münster | - | Colonia | 2:1 |
Alemania