| 1. Jornada | 25.07.2021 | RSC Anderlecht | - | Union Saint-Gilloise | 1:3 | ||||
| 2. Jornada | 01.08.2021 | Union Saint-Gilloise | - | Club Brugge KV | 0:1 | ||||
| 3. Jornada | 07.08.2021 | K Beerschot VA | - | Union Saint-Gilloise | 0:3 | ||||
| 4. Jornada | 14.08.2021 | Union Saint-Gilloise | - | KV Kortrijk | 2:0 |  |
|||
| 5. Jornada | 22.08.2021 | KV Mechelen | - | Union Saint-Gilloise | 3:1 | ||||
| 6. Jornada | 28.08.2021 | Union Saint-Gilloise | - | Standard Liège | 4:0 | ||||
| 7. Jornada | 12.09.2021 | KRC Genk | - | Union Saint-Gilloise | 1:1 | ||||
| 8. Jornada | 18.09.2021 | Union Saint-Gilloise | - | SV Zulte Waregem | 2:1 | ||||
| 9. Jornada | 26.09.2021 | Union Saint-Gilloise | - | Royal Antwerp FC | 1:2 | ||||
| 10. Jornada | 02.10.2021 | Cercle Brugge | - | Union Saint-Gilloise | 0:3 |
Bélgica