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| 09.04.2022 | 11:00 | Kickers Offenbach | - | SC Freiburg | 0:2 (0:2) | |
| 11:00 | Darmstadt | - | Bayern Múnich | 2:1 (1:1) | ||
| 11:00 | Ingolstadt | - | Eintracht Frankfurt | 1:2 (0:1) | ||
| 15:00 | Mainz | - | 1. FC Nürnberg | 3:5 (3:4) | ||
| 16:30 | 1. FC Heidenheim 1846 | - | SSV Ulm 1846 | 2:3 (1:2) | ||
| 10.04.2022 | 13:00 | Stuttgarter Kickers | - | Augsburgo | 1:3 (0:2) | |
| 13:00 | SpVgg Unterhaching | - | Stuttgart | 1:0 (1:0) | ||
| 13:00 | Karlsruher SC | - | Hessen Kassel | 6:0 (4:0) | ||
| 20.04.2022 | 18:00 | 1. FC Kaiserslautern | - | 1. FC Saarbrücken | 5:0 (1:0) | |
| 18:30 | FC-Astoria Walldorf | - | Hoffenheim | 3:3 (2:2) |
| » Clasificación | En casa | Fuera de casa | 1.ª vuelta | 2.ª vuelta | 1.ª parte | 2.ª parte |
| # | Equipo | P | V | E | D | Goles | DG | Pun. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Augsburgo | 18 | 12 | 4 | 2 | 51:30 | 21 | 40 |
| 2 |
|
1. FC Nürnberg | 18 | 13 | 1 | 4 | 41:26 | 15 | 40 |
| 3 |
|
Eintracht Frankfurt | 18 | 12 | 3 | 3 | 51:22 | 29 | 39 |
| 4 |
|
Stuttgart | 18 | 12 | 2 | 4 | 50:16 | 34 | 38 |
| 5 |
|
Mainz | 19 | 11 | 2 | 6 | 57:38 | 19 | 35 |
| 6 |
|
Hoffenheim | 18 | 9 | 5 | 4 | 58:32 | 26 | 32 |
| 7 |
|
SpVgg Unterhaching | 18 | 9 | 3 | 6 | 30:29 | 1 | 30 |
| 8 |
|
Bayern Múnich | 18 | 9 | 2 | 7 | 53:29 | 24 | 29 |
| 9 |
|
Darmstadt | 18 | 8 | 5 | 5 | 27:26 | 1 | 29 |
| 10 |
|
Karlsruher SC | 18 | 7 | 7 | 4 | 33:27 | 6 | 28 |
| 11 |
|
SC Freiburg | 19 | 8 | 4 | 7 | 39:34 | 5 | 28 |
| 12 |
|
1. FC Heidenheim 1846 | 18 | 7 | 4 | 7 | 32:27 | 5 | 25 |
| 13 |
|
1. FC Kaiserslautern | 18 | 8 | 1 | 9 | 39:47 | -8 | 25 |
| 14 |
|
FC-Astoria Walldorf | 18 | 5 | 7 | 6 | 32:33 | -1 | 22 |
| 15 |
|
Ingolstadt | 18 | 6 | 4 | 8 | 33:36 | -3 | 22 |
| 16 |
|
Stuttgarter Kickers | 18 | 6 | 2 | 10 | 33:48 | -15 | 20 |
| 17 |
|
SpVgg Greuther Fürth | 18 | 4 | 3 | 11 | 25:42 | -17 | 15 |
| 18 |
|
Kickers Offenbach | 18 | 4 | 2 | 12 | 20:44 | -24 | 14 |
| 19 |
|
SSV Ulm 1846 | 18 | 4 | 1 | 13 | 24:48 | -24 | 13 |
| 20 |
|
1. FC Saarbrücken | 18 | 4 | 0 | 14 | 17:41 | -24 | 12 |
| 21 |
|
Hessen Kassel | 18 | 1 | 0 | 17 | 7:77 | -70 | 3 |
| Playoff | |
| Descenso |
