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| 19.02.2022 | 11:00 | Stuttgarter Kickers | - | Hoffenheim | 0:1 (0:1) | |
| 12:30 | SpVgg Greuther Fürth | - | 1. FC Heidenheim 1846 | 2:1 (1:0) | ||
| 20.02.2022 | 11:00 | Ingolstadt | - | 1. FC Kaiserslautern | 0:3 (0:1) | |
| 11:00 | Bayern Múnich | - | Karlsruher SC | 4:4 (2:2) | ||
| 11:00 | 1. FC Nürnberg | - | SV Wehen Wiesbaden | 3:0 (1:0) | ||
| 13:00 | FSV Frankfurt | - | SV 07 Elversberg | 2:0 (1:0) | ||
| 13:00 | Augsburgo | - | TSV 1860 München | 4:2 (1:1) | ||
| 14:00 | SSV Reutlingen | - | Darmstadt | 0:1 (0:0) | ||
| 14:30 | SC Freiburg | - | Eintracht Frankfurt | 0:2 (0:0) | ||
| 16.03.2022 | 18:00 | Stuttgart | - | SpVgg Unterhaching | 4:0 (1:0) |
| » Clasificación | En casa | Fuera de casa | 1.ª vuelta | 2.ª vuelta | 1.ª parte | 2.ª parte |
| # | Equipo | P | V | E | D | Goles | DG | Pun. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Stuttgart | 14 | 12 | 2 | 0 | 49:13 | 36 | 38 |
| 2 |
|
SpVgg Unterhaching | 15 | 12 | 0 | 3 | 36:21 | 15 | 36 |
| 3 |
|
Mainz | 14 | 9 | 4 | 1 | 41:14 | 27 | 31 |
| 4 |
|
Hoffenheim | 14 | 10 | 0 | 4 | 37:21 | 16 | 30 |
| 5 |
|
SC Freiburg | 14 | 9 | 1 | 4 | 39:20 | 19 | 28 |
| 6 |
|
Augsburgo | 14 | 9 | 1 | 4 | 33:22 | 11 | 28 |
| 7 |
|
Bayern Múnich | 14 | 8 | 2 | 4 | 38:20 | 18 | 26 |
| 8 |
|
SpVgg Greuther Fürth | 14 | 8 | 2 | 4 | 21:17 | 4 | 26 |
| 9 |
|
1. FC Nürnberg | 15 | 7 | 2 | 6 | 36:25 | 11 | 23 |
| 10 |
|
Darmstadt | 15 | 7 | 0 | 8 | 26:33 | -7 | 21 |
| 11 |
|
FSV Frankfurt | 15 | 6 | 2 | 7 | 20:21 | -1 | 20 |
| 12 |
|
Eintracht Frankfurt | 15 | 5 | 4 | 6 | 22:25 | -3 | 19 |
| 13 |
|
TSV 1860 München | 14 | 6 | 1 | 7 | 16:20 | -4 | 19 |
| 14 |
|
Stuttgarter Kickers | 14 | 5 | 1 | 8 | 21:28 | -7 | 16 |
| 15 |
|
1. FC Heidenheim 1846 | 14 | 4 | 4 | 6 | 27:36 | -9 | 16 |
| 16 |
|
1. FC Kaiserslautern | 15 | 4 | 2 | 9 | 31:35 | -4 | 14 |
| 17 |
|
Karlsruher SC | 14 | 3 | 4 | 7 | 21:25 | -4 | 13 |
| 18 |
|
SV Wehen Wiesbaden | 14 | 3 | 1 | 10 | 15:38 | -23 | 10 |
| 19 |
|
SV 07 Elversberg | 14 | 2 | 1 | 11 | 8:37 | -29 | 7 |
| 20 |
|
Ingolstadt | 14 | 1 | 4 | 9 | 13:44 | -31 | 7 |
| 21 |
|
SSV Reutlingen | 14 | 0 | 2 | 12 | 10:45 | -35 | 2 |
| Playoff | |
| Descenso |
