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| 18.09.2021 | 11:00 | SpVgg Unterhaching | - | SC Freiburg | 2:4 (0:2) | |
| 11:00 | SV 07 Elversberg | - | 1. FC Kaiserslautern | 2:1 (0:1) | ||
| 11:00 | Karlsruher SC | - | TSV 1860 München | 2:1 (1:0) | ||
| 12:00 | Stuttgart | - | Darmstadt | 3:1 (2:0) | ||
| 13:00 | Bayern Múnich | - | SpVgg Greuther Fürth | 2:0 (1:0) | ||
| 16:00 | 1. FC Nürnberg | - | Ingolstadt | 2:2 (2:1) | ||
| 19.09.2021 | 11:00 | Mainz | - | Eintracht Frankfurt | 1:1 (1:0) | |
| 11:00 | SV Wehen Wiesbaden | - | 1. FC Heidenheim 1846 | 2:4 (1:2) | ||
| 14:00 | FSV Frankfurt | - | SSV Reutlingen | 2:2 (2:0) | ||
| 13.10.2021 | 19:00 | Stuttgarter Kickers | - | Augsburgo | 1:3 (0:1) |
| » Clasificación | En casa | Fuera de casa | 1.ª vuelta | 2.ª vuelta | 1.ª parte | 2.ª parte |
| # | Equipo | P | V | E | D | Goles | DG | Pun. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Stuttgart | 5 | 4 | 1 | 0 | 20:4 | 16 | 13 |
| 2 |
|
SpVgg Unterhaching | 5 | 4 | 0 | 1 | 15:8 | 7 | 12 |
| 3 |
|
Mainz | 5 | 3 | 2 | 0 | 13:3 | 10 | 11 |
| 4 |
|
SC Freiburg | 5 | 3 | 0 | 2 | 12:6 | 6 | 9 |
| 5 |
|
Hoffenheim | 4 | 3 | 0 | 1 | 13:8 | 5 | 9 |
| 6 |
|
Augsburgo | 5 | 3 | 0 | 2 | 12:11 | 1 | 9 |
| 7 |
|
Karlsruher SC | 5 | 2 | 2 | 1 | 7:5 | 2 | 8 |
| 8 |
|
Eintracht Frankfurt | 5 | 2 | 2 | 1 | 9:9 | 0 | 8 |
| 9 |
|
FSV Frankfurt | 5 | 2 | 1 | 2 | 7:7 | 0 | 7 |
| 10 |
|
SpVgg Greuther Fürth | 5 | 2 | 1 | 2 | 6:7 | -1 | 7 |
| 11 |
|
1. FC Kaiserslautern | 5 | 2 | 0 | 3 | 12:8 | 4 | 6 |
| 12 |
|
Bayern Múnich | 4 | 2 | 0 | 2 | 10:7 | 3 | 6 |
| 13 |
|
Darmstadt | 5 | 2 | 0 | 3 | 8:12 | -4 | 6 |
| 14 |
|
SV 07 Elversberg | 5 | 2 | 0 | 3 | 6:13 | -7 | 6 |
| 15 |
|
1. FC Heidenheim 1846 | 4 | 1 | 2 | 1 | 9:13 | -4 | 5 |
| 16 |
|
Ingolstadt | 5 | 1 | 2 | 2 | 5:12 | -7 | 5 |
| 17 |
|
1. FC Nürnberg | 5 | 1 | 1 | 3 | 8:9 | -1 | 4 |
| 18 |
|
TSV 1860 München | 4 | 1 | 1 | 2 | 6:7 | -1 | 4 |
| 19 |
|
Stuttgarter Kickers | 4 | 1 | 0 | 3 | 6:13 | -7 | 3 |
| 20 |
|
SV Wehen Wiesbaden | 5 | 1 | 0 | 4 | 6:14 | -8 | 3 |
| 21 |
|
SSV Reutlingen | 5 | 0 | 1 | 4 | 4:18 | -14 | 1 |
| Playoff | |
| Descenso |
