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| 01.04.2022 | 20:00 | Siegburger SV 04 | - | Borussia Freialdenhoven | 4:2 (2:1) | |
| 02.04.2022 | 20:00 | SV Deutz 05 | - | VfL 08 Vichttal | 0:2 (0:2) | |
| 03.04.2022 | 15:00 | Spvg Wesseling-Urfeld | - | SpVg Frechen 20 | 1:3 (1:2) | |
| 15:00 | Viktoria Arnoldsweiler | - | Blau-Weiß Friesdorf | 3:2 (1:0) | ||
| 15:00 | VfL Alfter | - | 1. FC Düren | 2:3 (0:2) | ||
| 15:00 | BC Viktoria Glesch-Paffendorf | - | FC Hennef 05 | 0:4 (0:2) | ||
| 15:00 | SV 1914 Eilendorf | - | SV Bergisch Gladbach 09 | 2:2 (0:1) | ||
| 15:30 | FC Pesch 1956 | - | Fortuna Köln II | 4:1 (2:0) | ||
| 14.04.2022 | 19:30 | SV Breinig | - | FC Hürth | 4:1 (1:1) |
| » Clasificación | En casa | Fuera de casa | 1.ª vuelta | 2.ª vuelta |
| # | Equipo | P | V | E | D | Goles | DG | Pun. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
1. FC Düren | 24 | 19 | 4 | 1 | 67:15 | 52 | 61 |
| 2 |
|
FC Hennef 05 | 24 | 17 | 4 | 3 | 57:17 | 40 | 55 |
| 3 |
|
SV Bergisch Gladbach 09 | 24 | 15 | 7 | 2 | 58:17 | 41 | 52 |
| 4 |
|
SpVg Frechen 20 | 24 | 14 | 4 | 6 | 51:29 | 22 | 46 |
| 5 |
|
Borussia Freialdenhoven | 24 | 12 | 3 | 9 | 41:35 | 6 | 39 |
| 6 |
|
FC Pesch 1956 | 24 | 10 | 8 | 6 | 53:32 | 21 | 38 |
| 7 |
|
Viktoria Arnoldsweiler | 24 | 12 | 2 | 10 | 43:37 | 6 | 38 |
| 8 |
|
Siegburger SV 04 | 24 | 10 | 7 | 7 | 42:33 | 9 | 37 |
| 9 |
|
BC Viktoria Glesch-Paffendorf | 24 | 10 | 5 | 9 | 37:32 | 5 | 35 |
| 10 |
|
Blau-Weiß Friesdorf | 24 | 9 | 6 | 9 | 38:40 | -2 | 33 |
| 11 |
|
VfL Alfter | 24 | 10 | 3 | 11 | 39:43 | -4 | 33 |
| 12 |
|
VfL 08 Vichttal | 24 | 9 | 4 | 11 | 43:47 | -4 | 31 |
| 13 |
|
FC Hürth | 24 | 9 | 4 | 11 | 33:46 | -13 | 31 |
| 14 |
|
Fortuna Köln II | 24 | 6 | 5 | 13 | 32:46 | -14 | 23 |
| 15 |
|
SV 1914 Eilendorf | 24 | 5 | 3 | 16 | 22:48 | -26 | 18 |
| 16 |
|
SV Breinig | 24 | 5 | 2 | 17 | 31:66 | -35 | 17 |
| 17 |
|
SV Deutz 05 | 24 | 4 | 3 | 17 | 24:57 | -33 | 15 |
| 18 |
|
Spvg Wesseling-Urfeld | 24 | 3 | 0 | 21 | 20:91 | -71 | 9 |
| Playoff | |
| Descenso |
