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| 01.05.2022 | 15:00 | 1. FC Düren | - | FC Hennef 05 | 5:1 (2:1) | |
| 15:00 | VfL Alfter | - | SpVg Frechen 20 | 0:1 (0:0) | ||
| 15:00 | Spvg Wesseling-Urfeld | - | SV 1914 Eilendorf | 2:4 (2:0) | ||
| 15:00 | BC Viktoria Glesch-Paffendorf | - | Blau-Weiß Friesdorf | 0:1 (0:0) | ||
| 15:00 | SV Breinig | - | SV Bergisch Gladbach 09 | 0:3 (0:3) | ||
| 15:30 | FC Pesch 1956 | - | Borussia Freialdenhoven | 3:3 (2:1) | ||
| 15:30 | Fortuna Köln II | - | VfL 08 Vichttal | 6:1 (2:1) | ||
| 15:30 | Siegburger SV 04 | - | Viktoria Arnoldsweiler | 5:2 (3:1) | ||
| 15:30 | SV Deutz 05 | - | FC Hürth | 2:4 (0:2) |
| » Clasificación | En casa | Fuera de casa | 1.ª vuelta | 2.ª vuelta |
| # | Equipo | P | V | E | D | Goles | DG | Pun. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
1. FC Düren | 28 | 23 | 4 | 1 | 88:18 | 70 | 73 |
| 2 |
|
FC Hennef 05 | 28 | 20 | 4 | 4 | 68:23 | 45 | 64 |
| 3 |
|
SV Bergisch Gladbach 09 | 28 | 18 | 8 | 2 | 67:19 | 48 | 62 |
| 4 |
|
SpVg Frechen 20 | 28 | 17 | 5 | 6 | 60:31 | 29 | 56 |
| 5 |
|
Borussia Freialdenhoven | 28 | 14 | 5 | 9 | 51:42 | 9 | 47 |
| 6 |
|
Blau-Weiß Friesdorf | 28 | 12 | 7 | 9 | 55:43 | 12 | 43 |
| 7 |
|
Siegburger SV 04 | 28 | 11 | 9 | 8 | 49:38 | 11 | 42 |
| 8 |
|
FC Pesch 1956 | 28 | 10 | 10 | 8 | 58:44 | 14 | 40 |
| 9 |
|
FC Hürth | 28 | 12 | 4 | 12 | 42:53 | -11 | 40 |
| 10 |
|
Viktoria Arnoldsweiler | 28 | 12 | 2 | 14 | 46:47 | -1 | 38 |
| 11 |
|
VfL Alfter | 28 | 11 | 4 | 13 | 44:48 | -4 | 37 |
| 12 |
|
BC Viktoria Glesch-Paffendorf | 28 | 10 | 6 | 12 | 39:37 | 2 | 36 |
| 13 |
|
VfL 08 Vichttal | 28 | 10 | 5 | 13 | 48:61 | -13 | 35 |
| 14 |
|
SV 1914 Eilendorf | 28 | 8 | 4 | 16 | 31:53 | -22 | 28 |
| 15 |
|
Fortuna Köln II | 28 | 7 | 6 | 15 | 41:57 | -16 | 27 |
| 16 |
|
SV Deutz 05 | 28 | 5 | 3 | 20 | 29:67 | -38 | 18 |
| 17 |
|
SV Breinig | 28 | 5 | 2 | 21 | 35:84 | -49 | 17 |
| 18 |
|
Spvg Wesseling-Urfeld | 28 | 3 | 0 | 25 | 25:111 | -86 | 9 |
| Playoff | |
| Descenso |
