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| 04.12.2020 | 18:00 | Fortuna Köln | - | Rot-Weiß Oberhausen | 1:0 (0:0) | |
| 19:30 | FC Wegberg-Beeck | - | Sportfreunde Lotte | 2:0 (0:0) | ||
| 05.12.2020 | 14:00 | Bonner SC | - | Wuppertaler SV | 3:3 (2:0) | |
| 14:00 | Borussia Dortmund II | - | SV 19 Straelen | 5:1 (1:0) | ||
| 14:00 | Preußen Münster | - | Bor. Mönchengladbach II | 1:2 (1:2) | ||
| 14:00 | Rot Weiss Ahlen | - | SV Bergisch Gladbach 09 | 1:1 (1:0) | ||
| 14:00 | Rot-Weiss Essen | - | Colonia | 3:1 (2:0) | ||
| 14:00 | SC Wiedenbrück | - | Alemannia Aachen | 0:1 (0:0) | ||
| 14:00 | SV Lippstadt 08 | - | SV Rödinghausen | 1:0 (0:0) | ||
| 06.12.2020 | 15:00 | Fortuna Düsseldorf II | - | Schalke II | 0:1 (0:1) |
| » Clasificación | En casa | Fuera de casa | 1.ª vuelta | 2.ª vuelta | 1.ª parte | 2.ª parte |
| # | Equipo | P | V | E | D | Goles | DG | Pun. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Rot-Weiss Essen | 18 | 13 | 5 | 0 | 41:10 | 31 | 44 |
| 2 |
|
Borussia Dortmund II | 18 | 13 | 4 | 1 | 50:15 | 35 | 43 |
| 3 |
|
Fortuna Köln | 18 | 9 | 6 | 3 | 35:20 | 15 | 33 |
| 4 |
|
Preußen Münster | 18 | 10 | 3 | 5 | 27:16 | 11 | 33 |
| 5 |
|
Fortuna Düsseldorf II | 18 | 9 | 5 | 4 | 33:14 | 19 | 32 |
| 6 |
|
Colonia | 18 | 8 | 6 | 4 | 27:18 | 9 | 30 |
| 7 |
|
Bor. Mönchengladbach II | 18 | 8 | 4 | 6 | 29:23 | 6 | 28 |
| 8 |
|
Schalke II | 18 | 7 | 7 | 4 | 25:19 | 6 | 28 |
| 9 |
|
Alemannia Aachen | 19 | 7 | 6 | 6 | 15:14 | 1 | 27 |
| 10 |
|
SV Rödinghausen | 18 | 7 | 5 | 6 | 21:17 | 4 | 26 |
| 11 |
|
SC Wiedenbrück | 18 | 5 | 8 | 5 | 28:28 | 0 | 23 |
| 12 |
|
SV 19 Straelen | 18 | 6 | 5 | 7 | 21:30 | -9 | 23 |
| 13 |
|
FC Wegberg-Beeck | 18 | 5 | 6 | 7 | 20:25 | -5 | 21 |
| 14 |
|
Rot-Weiß Oberhausen | 18 | 4 | 8 | 6 | 23:27 | -4 | 20 |
| 15 |
|
Wuppertaler SV | 19 | 5 | 4 | 10 | 21:34 | -13 | 19 |
| 16 |
|
SV Bergisch Gladbach 09 | 18 | 4 | 6 | 8 | 17:28 | -11 | 18 |
| 17 |
|
VfB Homberg | 18 | 5 | 2 | 11 | 17:33 | -16 | 17 |
| 18 |
|
SV Lippstadt 08 | 18 | 2 | 9 | 7 | 16:32 | -16 | 15 |
| 19 |
|
Sportfreunde Lotte | 18 | 3 | 4 | 11 | 17:39 | -22 | 13 |
| 20 |
|
Bonner SC | 18 | 3 | 3 | 12 | 17:37 | -20 | 12 |
| 21 |
|
Rot Weiss Ahlen | 18 | 1 | 6 | 11 | 17:38 | -21 | 9 |
| Ascenso | |
| Descenso |
