 |
 |
|
| I | Odense BK | - | Lokomotiv Sofia | 2:2 (2:0) | ||
| V | Lokomotiv Sofia | - | Odense BK | 2:1 (1:1) | ||
| I: 13.09.1978 | V: 27.09.1978 | Campeones: Lokomotiv Sofia | ||||
| I | Partizan | - | Dynamo Dresden | 2:0 (1:0) | ||
| V | Dynamo Dresden | - | Partizan | 5:4 (1:0, 2:0, 2:0) pn. | ||
| I: 13.09.1978 | V: 27.09.1978 17:00 | Campeones: Dynamo Dresden | ||||
| I | TJ Zbrojovka Brno | - | Újpesti Dózsa SC | 2:2 (0:1) | ||
| V | Újpesti Dózsa SC | - | TJ Zbrojovka Brno | 0:2 (0:2) | ||
| I: 13.09.1978 16:00 | V: 27.09.1978 17:45 | Campeones: TJ Zbrojovka Brno | ||||
| I | FK Vllaznia | - | Austria Wien | 2:0 (1:0) | ||
| V | Austria Wien | - | FK Vllaznia | 4:1 (2:0) | ||
| I: 13.09.1978 16:30 | V: 27.09.1978 18:00 | Campeones: Austria Wien | ||||
| I | Linfield FC | - | Lillestrøm SK | 0:0 (0:0) | ||
| V | Lillestrøm SK | - | Linfield FC | 1:0 (1:0) | ||
| I: 13.09.1978 18:30 | V: 27.09.1978 19:00 | Campeones: Lillestrøm SK | ||||
| I | Haka Valkeakoski | - | Dinamo Kiev | 0:1 (0:0) | ||
| V | Dinamo Kiev | - | Haka Valkeakoski | 3:1 (2:0) | ||
| I: 13.09.1978 19:00 | V: 27.09.1978 18:00 | Campeones: Dinamo Kiev | ||||
| I | Malmoe | - | Mónaco | 0:0 (0:0) | ||
| V | Mónaco | - | Malmoe | 0:1 (0:1) | ||
| I: 13.09.1978 19:00 | V: 27.09.1978 | Campeones: Malmoe | ||||
| I | Nottingham Forest | - | Liverpool | 2:0 (1:0) | ||
| V | Liverpool | - | Nottingham Forest | 0:0 (0:0) | ||
| I: 13.09.1978 19:30 | V: 27.09.1978 20:30 | Campeones: Nottingham Forest | ||||
| I | Omonia Nikosia | - | Bohemian FC | 2:1 (1:1) | ||
| V | Bohemian FC | - | Omonia Nikosia | 1:0 (1:0) | ||
| I: 13.09.1978 19:30 | V: 27.09.1978 16:00 | Campeones: Bohemian FC | ||||
| I | Colonia | - | ÍA Akranes | 4:1 (3:1) | ||
| V | ÍA Akranes | - | Colonia | 1:1 (1:0) | ||
| I: 13.09.1978 20:00 | V: 27.09.1978 18:00 | Campeones: Colonia | ||||
| I | Club Brugge KV | - | Wisła Kraków | 2:1 (2:0) | ||
| V | Wisła Kraków | - | Club Brugge KV | 3:1 (1:0) | ||
| I: 13.09.1978 20:00 | V: 27.09.1978 17:00 | Campeones: Wisła Kraków | ||||
| I | Grasshopper Club Zürich | - | Valletta FC | 8:0 (3:0) | ||
| V | Valletta FC | - | Grasshopper Club Zürich | 3:5 (0:1) | ||
| I: 13.09.1978 20:00 | V: 27.09.1978 15:30 | Campeones: Grasshopper Club Zürich | ||||
| I | Fenerbahçe | - | PSV | 2:1 (2:1) | ||
| V | PSV | - | Fenerbahçe | 6:1 (2:0) | ||
| I: 13.09.1978 20:30 | V: 27.09.1978 20:00 | Campeones: PSV | ||||
| I | Juventus | - | Rangers FC | 1:0 (1:0) | ||
| V | Rangers FC | - | Juventus | 2:0 (1:0) | ||
| I: 13.09.1978 20:30 | V: 27.09.1978 19:30 | Campeones: Rangers FC | ||||
| I | Real Madrid | - | Progrès Niedercorn | 5:0 (3:0) | ||
| V | Progrès Niedercorn | - | Real Madrid | 0:7 (0:3) | ||
| I: 13.09.1978 21:00 | V: 27.09.1978 20:00 | Campeones: Real Madrid | ||||
| I | AEK Athen | - | Oporto | 6:1 (4:0) | ||
| V | Oporto | - | AEK Athen | 4:1 (0:1) | ||
| I: 13.09.1978 21:00 | V: 27.09.1978 22:45 | Campeones: AEK Athen | ||||
